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临床医药

非编码RNA在高血压及其靶器官损害中的作用

  • 朱智显 ,
  • 陈新宇 ,
  • 姚昆鹏 ,
  • 彭丽琪 ,
  • 张小琴
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  • 1.湖南中医药大学,湖南 长沙 410208;

    2.湖南中医药大学第一附属医院,湖南 长沙 410007

朱智显,男,主治医师,研究方向:中医药防治心血管疾病

收稿日期: 2025-03-30

  修回日期: 2025-09-11

  录用日期: 2026-03-18

  网络出版日期: 2026-03-19

基金资助

湖南省自然科学基金项目(2026JJ82082);湖南省教育厅资助科研项目(25B0355);2023年度湖南中医药大学校院联合基金项目(2023XYLH036);湖南省自然科学基金青年项目(2021JJ40417);湖南省创新性省份建设专项抗击新冠肺炎项目(2020SK3009);湖南省科技人才托举工程项目(2020TJ-N01);全国名老中医药专家陈新宇传承工作室建设项目(国中医药人教函[2022]75号)

The Role of Non-coding RNA in Hypertension and Its Target Organ Damage

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  • 1.Hunan University of Traditional Chinese Medicine Hunan Changsha 410208, China
    2.The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine Hunan Changsha 410007, China

Received date: 2025-03-30

  Revised date: 2025-09-11

  Accepted date: 2026-03-18

  Online published: 2026-03-19

摘要

高血压病发病率逐年升高,且靶器官损害明显,可同时累及多个脏器。但早期症状不易察觉,多在出现临床并发症时得以诊断,严重威胁人们的身心健康,给社会公共卫生系统带来沉重负担。高血压病的发生机制错综复杂,仍不完全清楚,且目前缺乏有效、精准的预防和治疗措施。近年来,非编码RNA一跃成为疾病研究领域的热点,在肿瘤疾病、心血管疾病、神经系统疾病等的发生发展过程中发挥重要调控作用。本篇综述着重于阐述ncRNA在高血压病及心、肾、脑等靶器官损害的表达差异及作用机制,揭示其作为预防和治疗靶点的潜力。


本文引用格式

朱智显 , 陈新宇 , 姚昆鹏 , 彭丽琪 , 张小琴 .

非编码RNA在高血压及其靶器官损害中的作用

[J]. 中国医药导刊, 2026 , 28(2) : 181 -181-190 . DOI: magtech.2025.03.30-00002

Abstract

The incidence of hypertension is increasing year by year and the target organ damage is obvious can involve multiple organs at the same time. However the early symptoms are not easy to detect and most of them are diagnosed when there are clinical complications which seriously threatens people's physical and mental health and brings a heavy burden to the social public health system. The pathogenesis of hypertension is complex and not fully understood and there is a lack of effective and precise prevention and treatment measures. In recent years non-coding RNAnc RNAhas become a hot spot in the field of disease research which plays an important regulatory role in the occurrence and development of tumor diseases cardiovascular diseases and nervous system diseases. This review focuses on the differential expression and mechanism of ncRNA in hypertension and target organ damage such as heart kidney and brain and reveals its potential as a target for prevention and treatment.


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