老年重症肺炎合并呼吸衰竭患者血小板内皮细胞粘附分子-1、多配体蛋白聚糖-1表达水平及意义分析
收稿日期: 2025-07-07
修回日期: 2025-07-23
录用日期: 2026-03-18
网络出版日期: 2026-03-19
基金资助
空军军医大学科研项目（2021KYBJ01）
Expression Levels and Significance of Adhesion Molecule-1 and Polyligand Proteoglycan-1 in Platelet Endothelial Cells in Elderly Patients with Severe Pneumonia Complicated with Respiratory Failure
Received date: 2025-07-07
Revised date: 2025-07-23
Accepted date: 2026-03-18
Online published: 2026-03-19
目的：探究老年重症肺炎合并呼吸衰竭患者体内血小板内皮细胞粘附分子-1（PECAM-1）和多配体蛋白聚糖-1（SDC-1）表达水平及意义。方法：收集重症肺炎合并呼吸衰竭、重症肺炎、普通肺炎患者各69例分别为伴呼吸衰竭组、重症组和普通组。对比各组患者急性生理学与慢性健康状况评分Ⅱ（APACHEⅡ）、实验室指标、血清PECAM-1、SDC-1水平。结果：伴呼吸衰竭组APACHEⅡ评分、C反应蛋白和降钙素原水平均明显高于重症组和普通组（均P<0.05）；重症组APACHEⅡ评分、C反应蛋白和降钙素原水平均明显高于普通组（均P<0.05）。伴呼吸衰竭组氧合指数和血清PECAM-1水平均明显低于重症组和普通组，SDC-1水平高于重症组和普通组（均P<0.05）；重症组氧合指数明显低于普通组，血清PECAM-1和SDC-1水平高于普通组（均P<0.05）。纳入肺炎患者血清PECAM-1和SDC-1水平均与APACHEⅡ评分呈中等正相关（r=0.510、0.585，均P<0.05），血清PECAM-1、SDC-1水平均对重症肺炎患者伴发呼吸衰竭具有一定预测价值（AUC=0.746、0.790）。结论：重症肺炎合并呼吸衰竭患者体内PECAM-1和SDC-1呈高表达，两者表达水平均与患者病情严重程度密切相关，对重症肺炎伴发呼吸衰竭具有一定预测价值。
王荣
,
谢柏梅
,
王娟
.
老年重症肺炎合并呼吸衰竭患者血小板内皮细胞粘附分子-1、多配体蛋白聚糖-1表达水平及意义分析
Objective： To investigate the expression levels and significance of platelet endothelial cell adhesion molecule-1 （PECAM-1） and polyligand proteoglycan-1 （SDC-1） in elderly patients with severe pneumonia complicated with respiratory failure.Methods： A total of 69 patients with severe pneumonia combined with respiratory failure， severe pneumonia and common pneumonia were assigned to respiratory failure group， severe pneumonia group and common group respectively.Acute physiology and chronic health status score Ⅱ（APACHEⅡ）， laboratory indexes， serum PECAM-1 and SDC-1 levels were compared among all groups.Results： The APACHEⅡ score， C-reactive protein and procalcitonin in the group with respiratory failure were significantly higher than those in the severe group and the general group （all P < 0.05），and the APACHEⅡ score， C-reactive protein and procalcitonin in severe group were significantly higher than those in normal group （all P < 0.05）.The oxygenation index in the group with respiratory failure were significantly lower than those in the severe group and the general group， and serum PECAM-1， SDC-1 level was higher than that in the severe group and the general group （all P < 0.05）；and the oxygenation index in severe group were significantly lower than those in normal group， and serum PECAM-1， SDC-1 level was higher than that in normal group （all P < 0.05）.In addition， serum PECAM-1 and SDC-1 level was moderately positively correlated with the APACHEⅡ score （r=0.510， 0.585， all P < 0.05）， Serum PECAM-1 and SDC-1 levels had a certain predictive value for respiratory failure in patients with severe pneumonia （AUC=0.746， 0.790）.Conclusion： In patients with severe pneumonia complicated with respiratory failure， PECAM-1 and SDC-1 are highly expressed， and the expression levels of both are closely related to the severity of the patient's disease， which has certain predictive value for severe pneumonia complicated with respiratory failure.
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