吉兰-巴雷综合征（Guillain-Barré syndrome，GBS）是一种周围神经及周围神经根发生脱髓鞘病变的急性炎症性自身免疫病。临床中部分GBS患儿在应用各种现代医学手段治疗后，仍遗留有肢体感觉运动功能障碍，存在病情复发的现象，多数患儿存在前驱感染史。中医多将本病归属为“痿证”范畴。《黄帝内经》时期就已对痿证的病因病机有了较全面的阐述，并提出了“肺热叶焦”的核心病机及“治痿独取阳明”的治疗原则。但基于对《黄帝内经》痿证理论的总结及后世医家对《黄帝内经》相关条文的解读，本研究认为“独取阳明”并非“唯独”之意，单一地调治脾胃不能统领痿证的治疗。本研究结合儿童GBS多由外感而发、小儿“阳常有余”的生理特点及肺脾两脏的功能联系，总结出“外邪袭肺，郁而化热，肺热叶焦”为本病的核心病机，痰湿、血瘀为重要病理产物，当以标本兼治、补虚泻实为总体治则，以治肺为要，采取疏风宣肺、清热通络等方法，于急性期方选麻杏薏甘汤合桂枝加葛根汤加减方，并随症调整用药，且经临床案例佐证有效，可为临床诊疗提供新的思路。

Guillain-Barré syndrome （GBS） is an acute inflammatory autoimmune disease characterized by demyelination of peripheral nerves and nerve roots. In clinical practice， some pediatric GBS patients still experience limb sensory and motor dysfunction after various modern medical treatments， with a tendency for disease recurrence. Most GBS patients have a history of preceding infections. Traditional Chinese medicine often classifies this condition under the category of "flaccidity syndrome". As early as the "Huangdi Neijing" period， a relatively comprehensive explanation of the etiology and pathogenesis of flaccidity syndrome had already been provided， proposing the core pathogenesis of "lung heat scorching" and the treatment principle of "treating flaccidity syndrome by focusing on the Yangming meridian". However， based on summarizing the theories of flaccidity syndrome in the "Huangdi Neijing" and the interpretations by later physicians， this study argues that "focusing on the Yangming" does not imply exclusivity， and merely regulating the spleen and stomach cannot fully address flaccidity syndrome. Considering the etiology of pediatric GBS， the physiological characteristics of "excess of Yang in children"， and the functional connection between the lung and spleen， this study has identified "external pathogens invading the lung， stagnating and transforming into heat， heat scorching the lung " as the core pathogenesis of this disease. Phlegm-dampness and blood stasis are significant pathological byproducts. The overall treatment principle should be to address both symptoms and root causes， tonify the deficiency and purge the excess， with a focus on treating the lung. Methods such as dispersing wind， promoting lung function， clearing heat， and unblocking collaterals are employed. The modified formula of Ma Xing Yi Gan decoction combined with Gui Zhi Jia Ge Gen decoction has been clinically validated as effective， offering new insights for clinical diagnosis and treatment.