思维是人们认识世界、改造世界的根本方法和核心力量。观察事物、分析问题、解决矛盾、推动发展，均离不开科学思维的指引。药品安全是重大的政治问题、民生问题、经济问题和社会问题。当今时代，药品生产经营活动日趋复杂，传统监管方式已难以有效应对今日的风险挑战。全面提升药品安全工作的科学化、法治化、国际化、现代化水平，必须着力强化政治思维、科学思维、法治思维和社会思维等基本思维。本研究分别梳理并重点分析了各种基本思维的核心要义、法治贯通、实践挑战、基本规则，明确加强药品安全监管必须登高望远、深思熟虑，强化战略统筹，以政治思维领航铸魂，坚守药品监管根本方向；以科学思维格物致知，探索药品监管科学规律；以法治思维立规明矩，提升药品监管法治水平；以社会思维聚势合力，构建药品安全共治格局，积极迎接未来世界深刻变革，不断开创药品安全监管工作新局面。

 Thinking is the fundamental methodology and core driving force to understand and reshape the world. Observing things， analyzing problems， resolving conflicts， and driving progress all require the guidance of a scientific mindset. Drug safety is a critical political， livelihood， economic， and social issue. In today’s era， drug production and distribution activities are becoming increasingly complex， and traditional regulatory approaches can hardly cope with today’s risks and challenges effectively.To comprehensively advance the scientific， law-based， internationalized， and modernized standards of drug safety work， it is essential to strengthen the political， scientific， law-based， and social mindset. This study respectively sorts out and focuses on analyzing the core essence， penetration of the rule of law， practical challenges and basic rules of various basic ways of thinking. It is necessary to have a vision and a deep consideration of drug safety supervision and scientific supervision， to strengthen the overall strategic planning； apply a political mindset as an anchor to ensure unwavering adherence to the core direction of drug safety； apply a scientific mindset to pursue objective truth， abiding by the scientific laws of drug safety regulation； apply a law-based mindset as standard to uphold rules and enhance law-based governance of drug regulation； apply a social mindset as catalyst to build synergy and foster social collaborative governance that proactively embrace the deeper changes in the future world and continuously breaks new ground in drug safety regulation.