The Causal Relationship Between Gut Microbiota， Circulating Inflammatory Factors and Scoliosis

doi:10.1009-0959.2026.020006

Abstract

Abstract:

Objective： Based on Mendelian randomization （MR） analysis， the causal relationship between gut microbiota （GM）， circulating inflammatory factors （CIPs） and Scoliosis （SS） was discussed. Methods： Data for 211 GM， 91 CIPs and SS were obtained from the Genome-Wide Association Studies （GWAS） database. The inverse variance weighting （IVW） method was used as the main test in MR analysis. Sensitivity analysis was used to assess the robustness of MR results. Reverse MR Analysis was used to determine the directionality of causal relationships.Results： The results of the study showed that the levels of Eukaryotic translation initiation factor 4E-binding protein 1 and Caspase 8 in CIPs were positively correlated with SS（OR>1， P<0.05）， whereas high levels of Osteoprotegerin and Transforming growth factor-alpha （TGF-α） were negatively correlated with SS（OR<1， P<0.05）. In GM， Desulfovibrio， genus Eubacterium ventriosum group， genus Lachnospiraceae FCS020 group and genus Ruminococcus 6 were positively correlated with SS （OR>1， P<0.05）， whereas genus Bilophila， genus Eubacterium eligens group and genus Prevotella 9 were negatively correlated with SS （OR<1， P<0.05）. Heterogeneity and multiplicity tests confirmed the reliability of the MR analysis. Reverse MR analysis did not reveal that these risk and protective factors were reverse causally associated with SS. In addition， the studies have found no mediating role of CIPs in the causal relationship between GM and SS.Conclusion： In CIPs， 4E-BP1 and caspase 8 are risk factors for SS， while osteophosphorin and TGF-α are protective factors for SS. In GM， Desufovibrio， Eubacterium ventriosum， Lachnospiraceae FCS020 group and Ruminococcus 6 are the risk factors of SS， while Bilophilia， Eubacterium and Prevotella are the protective factors of SS. This study provides new directions and targets for the diagnosis， treatment and prevention strategies of SS.

Key words: , , Scoliosis； , Gut microbiota； , Circulating inflammatory factors； , Mendelian randomization analysis； , GWAS

CLC Number:

R682.3

ZHENG Li, ZENG Yong, HENG Hongquan, LUO Ying, FANG Miao, WANG Ping.

The Causal Relationship Between Gut Microbiota， Circulating Inflammatory Factors and Scoliosis [J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2026, 28(1): 108-108-113.

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