Expression Levels and Significance of Adhesion
Molecule-1 and Polyligand Proteoglycan-1 in Platelet
Endothelial Cells in Elderly Patients with Severe Pneumonia Complicated with
Respiratory Failure

doi:10.1009-0959.2026.030005

Abstract

Abstract:

Objective： To investigate the expression levels and significance of platelet endothelial cell adhesion molecule-1 （PECAM-1） and polyligand proteoglycan-1 （SDC-1） in elderly patients with severe pneumonia complicated with respiratory failure.Methods： A total of 69 patients with severe pneumonia combined with respiratory failure， severe pneumonia and common pneumonia were assigned to respiratory failure group， severe pneumonia group and common group respectively.Acute physiology and chronic health status score Ⅱ（APACHEⅡ）， laboratory indexes， serum PECAM-1 and SDC-1 levels were compared among all groups.Results： The APACHEⅡ score， C-reactive protein and procalcitonin in the group with respiratory failure were significantly higher than those in the severe group and the general group （all P < 0.05），and the APACHEⅡ score， C-reactive protein and procalcitonin in severe group were significantly higher than those in normal group （all P < 0.05）.The oxygenation index in the group with respiratory failure were significantly lower than those in the severe group and the general group， and serum PECAM-1， SDC-1 level was higher than that in the severe group and the general group （all P < 0.05）；and the oxygenation index in severe group were significantly lower than those in normal group， and serum PECAM-1， SDC-1 level was higher than that in normal group （all P < 0.05）.In addition， serum PECAM-1 and SDC-1 level was moderately positively correlated with the APACHEⅡ score （r=0.510， 0.585， all P < 0.05）， Serum PECAM-1 and SDC-1 levels had a certain predictive value for respiratory failure in patients with severe pneumonia （AUC=0.746， 0.790）.Conclusion： In patients with severe pneumonia complicated with respiratory failure， PECAM-1 and SDC-1 are highly expressed， and the expression levels of both are closely related to the severity of the patient's disease， which has certain predictive value for severe pneumonia complicated with respiratory failure.

Key words: Severe pneumonia； , Respiratory failure； , State of the disease； , Serum expression； , Platelet endothelial cell adhesion molecule-1； , Polyligand proteoglycan-1

CLC Number:

R563.8

WANG Rong, XIE Baimei, WANG Juan.

Expression Levels and Significance of Adhesion Molecule-1 and Polyligand Proteoglycan-1 in Platelet Endothelial Cells in Elderly Patients with Severe Pneumonia Complicated with Respiratory Failure [J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2026, 28(2): 176-176-180.

References

［1］朱轶，张忠满，邓晴，等.液体负平衡对重症肺炎患者预后的影响［J］.中华急诊医学杂志，2020，29（8）：1053-1058.

［2］ Phua J， Dean NC， Guo Q， et al. Severe community-acquired pneumonia： timely management measures in the first 24 hours［J］.Crit Care， 2016，20（1）：237-247.

［3］吴亚光，刘静，陈乐乐，等.qSOFA评分联合氧合指数对老年重症肺炎合并呼吸衰竭患者病情严重程度及预后的评估的临床价值［J］.临床和实验医学杂志，2023，22（10）：1038-1041.

［4］ Zhang ZK， Dou HW， Tu P， et al. Serum cytokine profiling reveals different immune response patterns during general and severe mycoplasma pneumoniae pneumonia［J］.Front Immunol， 2022，13（1）：1088725-1088736.

［5］李丽娟，刘颖梅，邢西迁，等.肺炎患者支气管肺泡灌洗液病原阳性率影响因素：多中心回顾性研究［J］.国际呼吸杂志，2018，38（17）：1281-1286.

［6］ Chen SN， Mai ZY，Mai JN， et al. E2F2 modulates cell adhesion through the transcriptional regulation of PECAM1 in multiple myeloma［J］.Br J Haematol， 2023，202（4）：840-855.

［7］刘刚，朱长举，刘奇.血小板内皮细胞黏附分子-1在急性肺损伤中的作用研究进展［J］.中国中西医结合急救杂志，2022，29（5）：633-635.

［8］ Zhang D， Li L， Chen Y， et al. Syndecan-1， an indicator of endothelial glycocalyx degradation， predicts outcome of patients admitted to an ICU with COVID-19［J］.Mol Med， 2021，27（1）：151-162.

［9］中华医学会呼吸病学分会.中国成人社区获得性肺炎诊断和治疗指南（2016年版）［J］.中华结核和呼吸杂志，2016，39（4）：253-279.

［10］阮小平. 呼吸衰竭诊断标准［J］.康颐，2020， 5（10）：41.

［11］ Dequin PF， Meziani F， Quenot JP， et al. Hydrocortisone in severe community-acquired pneumonia［J］.N Engl J Med， 2023，388（21）：1931-1941.

［12］ Lin CJ， Chang YC， Tsou MT， et al. Factors associated with hospitalization for community-acquired pneumonia in home health care patients in Taiwan［J］.Aging Clin Exp Res， 2020， 32（1）：149-155.

［13］马群，李卫阳，许蒙.老年重症肺炎并呼吸衰竭患者血清可溶性CD40配体和正五聚体蛋白-3水平变化及临床意义［J］.新乡医学院学报，2023，40（7）：659-663.

［14］张欣欣，罗源，杨庆斌，等.纤维支气管镜吸痰联合肺泡灌洗对重症肺炎并发呼吸衰竭患者疗效、CPIS评分及血清炎性指标水平的影响［J］.山东医药，2022，62（4）：86-88.

［15］吴亚光，刘静，陈乐乐，等.qSOFA评分联合氧合指数对老年重症肺炎合并呼吸衰竭患者病情严重程度及预后的评估的临床价值［J］.临床和实验医学杂志，2023，22（10）：1038-1041.

［16］杨燕娜，洪开听，范贤斌.血常规、肺表面活性蛋白和T淋巴细胞水平与肺炎患儿病情严重程度的相关性［J］.中国妇幼保健，2019，34（22）：5216-5218.

［17］ Kovacs-Kàsa A， Varn MN， Verin AD， et al. Method for the culture of mouse pulmonary microvascular endothelial cells［J］.Sci Pages Pulmonol， 2017，1（1）：7-18.

［18］ Chen X， Chen J， Liu S， et al. PECAM-1 mediates temsirolimus-induced increase in neutrophil transendothelial migration that leads to lung injury［J］.Biochemical and Biophysical Research Communications， 2023，682：180-186.

［19］ Schønemann LM， Itenov TS， Larsson JE， et al. Novel subgroups in acute respiratory failure based on the trajectories of three endotheliopathy biomarkers： a cohort study［J］.Acta Anaesthesiol Scand， 2023，67（7）：896-908.

［20］ Villar J， Zhang H， Slutsky AS. Lung repair and regeneration in ARDS： role of PECAM1 and wnt signaling［J］.Chest， 2019，155（3）：587-594.

［21］ Zhang D， Li L， Chen Y， et al. Syndecan-1， an indicator of endothelial glycocalyx degradation， predicts outcome of patients admitted to an ICU with COVID-19［J］.Mol Med， 2021，27（1）：151-161.

［22］ Kajita Y， Terashima T， Mori H， et al. A longitudinal change of syndecan-1 predicts risk of acute respiratory distress syndrome and cumulative fluid balance in patients with septic shock： a preliminary study［J］.J Intensive Care， 2021，9（1）：27-37.

［23］ Smart L， Bosio E， Macdonald SPJ， et al. Glycocalyx biomarker syndecan-1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia， compared to endocan［J］.J Crit Care， 2018，47：93-98.

Expression Levels and Significance of Adhesion Molecule-1 and Polyligand Proteoglycan-1 in Platelet Endothelial Cells in Elderly Patients with Severe Pneumonia Complicated with Respiratory Failure

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