Research Progress on the Anti-Gastric
Cancer Effects and Mechanisms of Astragaloside IV

doi:10.1009-0959.2026.050030

Abstract

Abstract:

The high mortality rate of gastric cancer （GC）， chemoresistance and significant toxic side effects associated with current therapies for GC necessitate the search for low-toxicity and highly effective adjuvant treatment strategies. As the key active ingredient of the traditional Chinese medicine Astragalus membranaceus， Astragaloside IV （AS-IV） possesses extensive pharmacological properties. Characterized by its low toxicity， multi-target action， and cost-effectiveness， AS-IV has emerged as a promising candidate for the comprehensive treatment of GC. This article systematically reviews the mechanisms of action and research progress regarding AS-IV intervention throughout the entire pathological course of GC. Current evidence indicates that AS-IV can exert multi-dimensional intervention effects on the entire course of GC. In the initiation stage， it hinders the inflammation-cancer transition， protects the gastric mucosal barrier， and reverses precancerous lesions. In advanced GC， AS-IV induces tumor cell apoptosis by regulating multiple key signaling pathways while concurrently inhibiting tumor invasion and metastasis. Regarding the tumor microenvironment （TME）， it targets and remodels interstitial cell functions， alleviates the immunosuppressive state， and suppresses tumor angiogenesis. Furthermore， AS-IV enhances the sensitivity of GC cells to clinically common chemotherapeutic agents and reverses drug resistance， thereby exerting synergistic efficacy and reducing toxicity. Despite the significant potential of AS-IV in GC intervention， current research is largely confined to cell and animal experiments. Limitations such as low bioavailability and the lack of systematic elucidation of its mechanisms hinder its clinical translation. Future studies should deepen the investigation utilizing advanced experimental models， novel formulation technologies， and multi-omics approaches to facilitate the transition from bench to bedside and provide scientific basis for the potential incorporation of AS-IV into standardized GC treatment regimens.

Key words: Astragaloside IV； , Gastric cancer； , Inflammation-cancer transition； , Apoptosis； , Epithelial-mesenchymal transition； , Tumor microenvironment； , Chemosensitization； , Reversal of drug resistance

CLC Number:

R285
R735.2

WANG Yuqin, SONG Dengqin, ZHOU Dong, CHEN Hongci, ZHANG Xiong, ZHANG Meng.

Research Progress on the Anti-Gastric Cancer Effects and Mechanisms of Astragaloside IV [J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2026, 28(5): 568-568-572.

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Research Progress on the Anti-Gastric Cancer Effects and Mechanisms of Astragaloside IV

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