CHINESE JOURNAL OF MEDICINAL GUIDE ›› 2026, Vol. 28 ›› Issue (5): 605-605-610.doi: 10.1009-0959.2026.050017

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Effects of Qishenjiang Decoction on Serum Levels of VEGF ADMA and sST2 in Patients with Chronic Heart Failure

FU Xueting1, WU Xiaodong2, ZHAO Mingfen3*   

  1. 1.The Fourth Clinical Medical College of Xinjiang Medical University Xinjiang Urumqi 830054, China
    2.Midong District Hospital of Traditional Chinese Medicine Xinjiang Urumqi 831400, China
    3.Affiliated Hospital of Traditional Chinese Medicine Xinjiang Medical University Xinjiang Urumqi 830054, China
  • Received:2025-12-25 Revised:2026-02-15 Accepted:2026-04-20 Online:2026-05-28 Published:2026-06-29

Abstract:

Objective: To investigate the effects of qishenjiang decoction on vascular endothelial growth factor VEGF), asymmetric dimethylarginine ADMA), soluble suppression of tumorigenicity 2 sST2), and N-terminal pro-B-type natriuretic peptide NT-proBNP), and key biomarkers in patients with chronic heart failure and to explore the potential mechanismsthereby providing evidence for optimizing comprehensive treatment strategies for chronic heart failure.Methods: A total of 92 patients with chronic heart failure who visited our hospital and met the inclusion criteria were enrolled and randomly assigned to the control group and the observation groupwith 46 patients in each group.Both groups received standardized conventional therapy. In additionthe observation group was treated with qishenjiang decoction for 12 weeks. Serum NT-proBNP ADMA VEGF and sST2 levels as well as echocardiographic parameters and cardiac function indicators of the patients were measured before treatment and after 12 weeks of treatment. Changes in these indicators were compared between the two groups with emphasis on improvements in angiogenic capacityendothelial function and inflammatory remodeling status.Results: After treatment the serum NT-proBNP levels of patients decreased in both groups compared with baseline P<0.001), and the post-treatment NT-proBNP level in the observation group was lower than that in the control group t=2.530P=0.014. After treatment serum ADMA levels of patients in the observation group were lower than those in the control group t=2.319P=0.024. Serum VEGF levels of patients increased in both groups after treatment compared with baseline P<0.001), and the post-treatment VEGF level in the observation group was higher than that in the control group t=2.052P=0.044. Serum sST2 levels of patients decreased in both groups after treatment compared with baseline P<0.001), and the post-treatment sST2 level in the observation group was lower than that in the control group t=2.270P=0.026. After treatment patients in the observation group showed significant improvements in left ventricular ejection fraction LVEF), left ventricular end-systolic diameter LVESD), and fractional shortening FS compared with baseline P<0.05.Conclusion: Qishenjiang decoction may improve angiogenesis impairment in patients with chronic heart failure through multi-target synergistic regulation of the VEGF-mediated angiogenic pathway the ADMA-related endothelial function axis and the sST2-associated inflammatory signaling network.


Key words: Chronic heart failure , Integrated traditional Chinese and western medicine , Angiogenic dysfunction , Qishenjiang decoction

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