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Relationship between the Risk of MACE during the Vulnerable Phase and Relevant Test Indexes in Patients with Acute Heart Failure
Received date: 2024-12-10
Revised date: 2025-08-05
Accepted date: 2025-09-30
Online published: 2025-11-18
Objective： To explore the risk of major adverse cardiovascular events （MACE） in patients with acute heart failure （AHF） during the vulnerable phase， and analyze the impact of relevant test indexes on MACE.Methods： A retrospective analysis was conducted on the clinical data of 200 patients with AHF who were admitted to the hospital from January 2020 to November 2024. According to the occurrence of MACE during the vulnerable phase， 57 patients were included in the MACE group and 143 patients were included in the non-MACE group. Baseline data and relevant laboratory test indexes of the two groups were compared. Cox hazards regression model was used to analyze the independent risk factors for MACE in patients with AHF during the vulnerable phase. Receiver operating characteristic （ROC） curves were used to evaluate the predictive value of different indexes for MACE.Results： There were statistically significant differences in age， cardiac function classification， B-type natriuretic peptide （BNP）， hematocrit and pan-immune inflammation value （PIV） between the MACE group and the non-MACE group （P<0.05）. Multivariate Cox hazards regression analysis showed that BNP ［HR （95%CI）=1.994 （1.293-3.075）］， hematocrit ［HR （95%CI）=0.477 （0.347-0.657）］ and PIV ［HR （95%CI）=2.192 （1.628-2.953）］ were factors influencing the occurrence of MACE in patients with AHF during the vulnerable phase （P<0.05）. The areas under the curve （AUCs） of BNP， hematocrit and PIV for predicting the occurrence of MACE were 0.666， 0.743 and 0.746， without significant difference （P>0.05）. The AUC of joint prediction using the three indicators was 0.876， which was greater than that of each indicator （P<0.05）.Conclusion： Elevated BNP and PIV， and decreased hematocrit are related to increased risk of MACE in patients with AHF during the vulnerable phase. The three indexes have certain predictive value for the occurrence of MACE， and their combined use can further improve predictive efficacy.
Qing Xie
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Relationship between the Risk of MACE during the
Vulnerable Phase and Relevant Test Indexes in Patients with Acute Heart Failure
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