CHINESE JOURNAL OF MEDICINAL GUIDE >
Epidemiological Characteristics of Multi-Drug Resistant Mycobacterium Tuberculosis and Analysis of Factors Affecting Patient Treatment Adherence
Received date: 2025-03-18
Revised date: 2025-04-22
Accepted date: 2025-11-12
Online published: 2025-11-18
Objective： To investigate the epidemiological characteristics of multi-drug resistant mycobacterium tuberculosis （MDR-TB） and identify factors influencing patient treatment adherence.Methods： A total of 265 MDR-TB patients （265 strains） were selected between February 2020 and February 2024. The temporal and seasonal distribution of clinical tuberculosis symptoms was examined. Patients completed a questionnaire collecting information on age， sex， marital status， education level， and medication adherence. Adherence was assessed， and factors influencing adherence were analyzed.Results： The analysis revealed that April had the highest proportion of clinical tuberculosis symptom onset （16.60%）， while September had the lowest （3.40%）. Spring had the highest number of cases （111 cases， 41.89%）， followed by winter （81 cases， 30.57%）， indicating a seasonal peak in spring and winter. 265 strains of divergent tuberculosis showed resistant to more than two tested drugs， and the overall resistance rate was 100%， among which the drugs with high resistance rate were flunolone and aminosalicylic acid， with a resistance rate of 70.57%， followed by isoniazid （59.62%）.Patients in the high-adherence group were younger （≥60 years）， less likely to have a history of alcohol consumption， more likely to exercise regularly， more likely to have participated in TB treatment training， and had greater awareness of core TB knowledge compared to the low-adherence group （P<0.05）. No significant differences were observed between the groups in terms of sex， marital status， education level， income， chronic comorbidities， Bacillus Calmette-Guérin （BCG） vaccination， smoking history， or the distance from their home to the hospital （P>0.05）. Logistic regression analysis indicated that age ≥60 years and a history of alcohol consumption increased the risk of poor adherence， while regular exercise， participation in TB treatment training， and knowledge of core TB information reduced the risk of poor adherence.Conclusion： Among MDR-TB patients， the highest proportion of clinical symptom onset occurred in April， the lowest in September， with spring and winter showing relatively higher incidence. For treatment adherence， age >60 years and alcohol consumption were associated with increased risk of poor adherence， whereas regular exercise， participation in TB treatment training， and greater awareness of core TB knowledge were associated with reduced risk.
ZUO Yangbin, LI Jin, LIN Tianyu, WU Lijuan, CHEN Chunxi
.
Epidemiological Characteristics of Multi-Drug
Resistant Mycobacterium Tuberculosis and Analysis of Factors Affecting Patient
Treatment Adherence
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