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Epigenetic Mechanism Research Hotspots and Development Trend of Differentiation of Human Amniotic Fluid Stem Cells Based on CiteSpace
Received date: 2024-12-10
Revised date: 2025-06-09
Accepted date: 2025-11-15
Online published: 2025-12-03
Objective： Through visual analysis of the research literature on epigenetic regulatory mechanisms during the differentiation of human amniotic fluid stem cells （hAFSCs）， to analyze the research hotspots and future trends in this field at home and abroad， aiming to deepen the understanding of the molecular mechanisms of pluripotency maintenance and differentiation of hAFSCs， and provide a solid theoretical basis for cell therapy， regenerative medicine， and the development of novel treatment strategies.Methods： With "human amniotic fluid stem cells" "differentiation" "epigenetic inheritance" and "methylation" as the main topics， the relevant literatures from January 2001 to May 2024 were searched in PubMed database. Excel software was used to draw the trend chart of the annual publication volume， and CiteSpace 6.2.R4 tool was used to draw the knowledge graph， and nodes such as author， country and keywords were analyzed.Results： The study included 601 articles contributed by 987 researchers worldwide， with Collas Philippe being one of the most active authors in this field with the most published articles （number=14）. Keyword co-occurrence analysis shows that "regenerative medicine" and "gene expression" are the focus of research in this field in recent years. Keyword breakout analysis revealed that "epigenetic modification" "drug resistance" "induced pluripotent stem cells" "stem cell research" and "DNA hydroxymethylation" were the current research hotspots， which provided the direction for subsequent research.Conclusion： In recent years， significant progress has been made in epigenetic regulatory mechanisms during hAFSCs differentiation， which not only reveals more key regulatory factors and signaling pathways，but also deepens the understanding of cell fateful mechanisms. The future researches we should focus on hot spots， dig deep into the differentiation mechanism of hAFSCs， and pay attention to the fine epigenetic regulation， so as to promote the precision cell therapy strategy and promote the innovative development of cell therapy and regenerative medicine.
Huan-Ying LOU
,
LI Yi Yi
.
Epigenetic Mechanism Research Hotspots and
Development Trend of Differentiation of Human Amniotic Fluid Stem Cells Based
on CiteSpace
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