CHINESE JOURNAL OF MEDICINAL GUIDE >
Analysis on Clinical Trial Registration Characteristics of Nasopharyngeal Carcinoma Based on Data of ClinicalTrials.gov and ChiCTR
Received date: 2025-06-09
Revised date: 2025-10-11
Accepted date: 2025-12-03
Online published: 2025-12-17
Objective： To investigate the development situation and registration characteristics of nasopharyngeal carcinoma clinical trial at home and abroad.Methods： The nasopharyngeal carcinoma clinical trials registered on ClinicalTrials.gov and ChiCTR up to March 20， 2025 were retrieved. The quantity changes， basic characteristics， and methodological design of these trials were statistically analyzed.Results： A total of 1116 nasopharyngeal carcinoma clinical trials from ClinicalTrials.gov and 360 nasopharyngeal carcinoma clinical trials from ChiCTR were retrieved out. Most nasopharyngeal carcinoma clinical trials were conducted in China， especially in Guangdong province. The disease staging was mainly characterized by local advanced stage， recurrent and metastasis disease. The trial types were mainly interventional studies， with the primary purpose of disease treatment. Most clinical trials were in the early exploratory stage， and the vast majority of trials had a sample size of less than 200 cases. The most common trial designs were parallel design and single-arm design. Most trials adopted non-randomized and non-blinded designs. The main intervention measures included chemotherapy and radiotherapy. The main therapeutic targets included PD-1/PD-L1， VEGF， EGFR and cytotoxic chemotherapy drugs， etc. The common primary endpoints were survival-related endpoints.Conclusion： The number of clinical trials for nasopharyngeal carcinoma in China is currently in a leading position. It is suggested that Chinese researchers fully leverage advantage of clinical resources， improve clinical trial designs， strengthen regional research collaboration， and lead global nasopharyngeal carcinoma clinical research to a new level.
Jing-long HE
.
Analysis on Clinical Trial Registration
Characteristics of Nasopharyngeal Carcinoma Based on Data of ClinicalTrials.gov
and ChiCTR
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