Research on the Mechanism of Action of Quyu Shengxin Formula in Treating Cerebral Infarction Based on Network Pharmacology and Molecular Docking

  • Li - Yunze
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  • 1.Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine
    Jiangsu Nanjing 210029, China
    2.Lianyungang Hopital of Jiangsu Province Hospital of Chinese Medicine/Lianyungang Hospital of Traditional Chinese Medicine Jiangsu Lianyungang 222002, China

Received date: 2024-09-29

  Revised date: 2025-06-14

  Accepted date: 2025-08-02

  Online published: 2025-12-17

Supported by

基于周细胞PDGFRβ信号研究通脑饮“祛瘀生新”促进缺血性脑卒中后血管新生的作用机制研究(MS2022016)

Abstract

Objective: To conduct a more scientific and comprehensive study on the action mechanism of quyu shengxin formula and inherit the clinical experience of professor Zhou Zhongying, network pharmacology and molecular docking techniques were employed to explore its mechanism of action in treating cerebral infarction.Methods: The effective active components and target proteins of the quyu shengxin formula were obtained through the TCMSP database, HERB database, and literature retrieval. Meanwhile, typical patient cases treated with the agreed prescription quyu shengxin formula were analyzed.Results: The clinical application of quyu shengxin formula has confirmed that it can effectively alleviate the neurological deficit symptoms of cerebral infarction patients and improve their prognosis. Network pharmacology research revealed that the quyu shengxin formula consists of 96 effctive components and 479 target proteins. The GO enrichment analysis encompassed 4046 items. The KEGG pathway enrichment analysis included 199 KEGG pathways. The molecular docking results indicated that the key components and core target proteins exhibited favorable binding effects. The main active components of the quyu shengxin formula are arachidonic acid, capsaicin, kaempferol, phenylmalonic acid, and rhynchophylline. It may exert the therapeutic effect on cerebral infarction by interfering in lipid and atherosclerosis, sphingolipid signaling pathways, and activating the brain-kidney-intestine axis.Conclusion: Traditional agreed prescription quyu shengxin formula, which aims to remove brain stasis, generate new vessels, and promote blood circulation for treating cerebral infarction, can improve the prognosis of patients. Its potential mechanism of action may be closely related to biological processes such as angiogenesis, apoptosis, anti-inflammation, and the brain-kidney-intestine axis, providing clues and a basis for subsequent experimental research and new drug development.

Cite this article

Li - Yunze .

Research on the Mechanism of Action of Quyu Shengxin Formula in Treating Cerebral Infarction Based on Network Pharmacology and Molecular Docking

[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2025 , 27(10) : 1018 -1018-1025 . DOI: magtech.2024.09.29-00005

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