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Study on Analgesic Characteristics of Jinlingzi San and Its Difference with Single Componee Analgesia
Received date: 2025-03-18
Revised date: 2025-07-29
Accepted date: 2025-11-15
Online published: 2025-12-24
Objective： To investigate the analgesic characteristics of Jinlingzi San， and explore the analgesic differences of Jinlingzi San and its single componet.Methods： To compare the analgesic effects of Jinlingzi San and its single componet， acute pain models （thermal tail flick， acetic acid writhing， and postoperative pain） and chronic pain models sciatic nerve （chronic constriction injury （CCI） induced neuropathic pain in rats， primary liver cancer pain in rats and tibia bone cavity tumor cell implantation （TCI） in rats） were used. In a variety of pain behavior tests， the analgesic effects of Jinlingzi San and its single componet were compared. In addition， the preliminary exploration of the differential analgesic material basis of Jinlingzi Powder and its single componet was conducted through HPLC-MS.Results： Intragastric administration of 12 g·kg-1 Jinlingzi San， Melia toosendan Sieb. et Zucc. and Corydalis yanhusuo could effectively relieve the pain caused by thermal tail flicle in mice， effectively reduce the number of writhing， relieve postoperative acute pain， relieve neuropathic pain induced by CCI， bone cancer pain induced by TCI and primary liver cancer pain. Moreover， compared with the 12 g·kg-1 of Toosendan Seed and Corydalis yanhusuo， the analgesic effect of 12 g·kg-1 of Jinglingzi San was better than that of the single drug groups. Further， HPLC-MS was used to compare the main analgesic active ingredients in Jinglingzi San and its single componet， and it was found that the contents of six alkaloids such as tetrahydro palmatine in the Jinglingzi San compound formula were different from those in the single componet， suggesting that the compatibility of the compound formula may enhance the efficacy by changing the content of active ingredients and the synergistic effect.Conclusion： Through the establishment of various acute and chronic pain models， it was found that the analgesic effect of Jinlingzi San （12 g·kg-1） was better than that of toosendania or Corydalis yanhusuo. The changes in the content of active ingredients and the synergistic effects may be the reason for the stronger effect of the compound than that of the single drug. In-depth study of the above aspects， can further reveal the analgesic mechanism of Jinlingzi San， and provide scientific basis for its clinical application and development.
Jin YANG
,
嘉豪 唐
,
Wen ling Dai
.
Study on Analgesic Characteristics of Jinlingzi
San and Its Difference with Single Componee Analgesia
［1］ Raja SN， Carr DB， Cohen M， et al. The revised International Association for the Study of Pain definition of pain： concepts， challenges， and compromises［J］.Pain， 2020，161（9）：1976-1982.
［2］ 宋学军，樊碧发，万有，等.国际疼痛学会新版疼痛定义修订简析［J］.中国疼痛医学杂志，2020，26（9）：641-644.
［3］ 王怡珍，梁绿圆，曹佳蕾，等.经典名方金铃子散关键信息考证与现代研究进展［J］.中国实验方剂学杂志，2024，30（24）：215-223.
［4］ 胡楠，孟彦彬，单思雨，等.基于LC-MS/MS的金铃子散单味药及复方在大鼠体内的药代动力学研究［J］.中国中药杂志，2025，50（5）：1385-1391.
［5］ 刘喜平，李沛清.金铃子散的传统功用与现代研究关联分析［J］.中成药，2011，33（9）：1578-1581.
［6］ 王红梅，韩海啸，张立平.基于网络药理学分析金铃子散治疗消化性溃疡作用机制研究［J］.辽宁中医药大学学报，2022，24（8）：58-64.
［7］ 贺静，陈园园，冯婷丽，等.针刺联合金铃子散治疗气滞血瘀型晚期胃癌疼痛患者疗效观察［J］.湖北中医药大学学报，2024，26（1）：93-95.
［8］ 武倩茹.川楝子中三萜类化学成分的研究［J］.山西医科大学学报，2024，55（1）：104-107.
［9］ 张雨，范蒙蒙，朱建光，等.川楝子化学成分、药理及毒理研究进展［J］.中华中医药学刊，2023，41（12）：218-226.
［10］ 孙梦雪，李玉婷.延胡索乙素的药理作用研究进展［J］.山东化工，2024，53（13）：130-133.
［11］ 陈斯.延胡索化学成分和药理作用研究进展［J］.中医药信息，2021，38（7）：78-82.
［12］ 焦苗苗，王旭，周娜，等.延胡索、乌药、金铃子散、小活络丹对神经病理性疼痛镇痛作用的比较［J］.神经药理学报，2020，10（2）：1-6.
［13］ Zhou MY， Yao CH， Yang YJ， et al. Based on spinal central sensitization creating analgesic screening approach to excavate anti-neuropathic pain ingredients of Corydalis yanhusuo W.T.Wang［J］.J Ethnopharmacol， 2024，319（Pt 1）：117084.
［14］ Brennan TJ， Vandermeulen EP， Gebhart GF. Characterization of a rat model of incisional pain［J］.Pain， 1996，64（3）：493-502.
［15］ Bennett GJ， Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man［J］.Pain， 1988，33（1）：87-107.
［16］ Jimenez-Andrade JM， Mantyh WG， Bloom AP， et al. Bone cancer pain［J］.Ann N Y Acad Sci， 2010，1198：173-181.
［17］ Ushida T. Chronic pain： definition/conception/classification of pain［J］.Brain Nerve， 2023，75（3）：201-205.
［18］ Macres S， Aldwinckle RJ， Saldahna U， et al. Reconceptualizing acute pain management in the 21st century［J］.Adv Anesth， 2023，41（1）：87-110.
［19］ Dahan A， Hellinga MD， Niesters M， et al. Pain in cancer［J］.Ned Tijdschr Geneeskd， 2023，167：D7768.
［20］ Bayrer JR， Castro J， Venkataraman A， et al. Gut enterochromaffin cells drive visceral pain and anxiety［J］.Nature， 2023，616（7955）：137-142.
［21］ 傅斌，范姝，万军.天蟾胶囊外周和中枢镇痛效应差异实验研究［J］.中草药，2022，53（3）：783-787.
［22］ 孙啸，孙学礼.重新认识疼痛——新解读、新分类和新治疗［J］.华西医学，2021，36（8）：1139-1143.
［23］ 杨永华.疼痛类型不同治疗管理有异［J］.健康向导，2024，30（3）：25.
［24］ Li HB， Huang L， Ni JY， et al. Traditional Chinese medicine in the treatment of adverse reactions after TACE for primary hepatic carcinoma： effect， mechanism， and potential advantages［J］.Phytomedicine， 2024，135：156244.
［25］ 王翠芳.金铃子散及其拆方抗炎镇痛的代谢组学研究［D］.广东药科大学，2019.
［26］ Dai WL， Bao YN， Fan JF， et al. Blockade of spinal dopamine D1/D2 receptor suppresses activation of NMDA receptor through Gαq and Src kinase to attenuate chronic bone cancer pain［J］.J Adv Res， 2021，28：139-48.
［27］ 史杰，王芳.川楝素对TRAIL抗肝癌活性及其机制研究［J］.浙江中西医结合杂志，2017，27（11）：936-939，946.
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