Objective： To explore the value of integrating chain-based quality control with digital management in hospital pharmacy management， and to evaluate its role in improving the quality of pharmaceutical services.Methods： A before-and-after controlled study was conducted， in the outpatient pharmacy of our hospital. Traditional management procedures were implemented from October 2023 to September 2024， serving as the control group （750 prescriptions randomly sampled）. From October 2024 to September 2025， a comprehensive management model combining chain-based quality control and digital management was applied as the observation group （750 prescriptions randomly sampled）.The two groups were compared across multiple indicators， including dispensing errors， pharmacy complaints， pharmacist work efficiency， pharmacy management quality， drug management quality， and patient satisfaction.Results： The dispensing error rate and complaint rate in the observation group were significantly lower than those in the control group （P<0.05）. In terms of work efficiency， the average daily number of prescriptions dispensed in the observation group was higher， than the coutrol group while the dispensing time required per prescription and daily inventory checking time were reduced （P<0.05）. Regarding pharmacy management， the observation group achieved higher scores in cleanliness， rational drug classification， and compliance with storage conditions （P<0.05）. In drug management， the scores of drug management standardization and inventory turnover rate in the observation group increased， and drug loss rate reduced （P<0.05）. In patient satisfaction， the overall satisfaction in the observation group reached 95.67%， higher than 86.33% in the control group （P<0.05）.Conclusion： The combination of chain-based quality control and digital management can effectively reduce dispensing errors and disputes， improve pharmacist wore efficiency and pharmacy operation quality， and promote refined， standardized， and traceable drug management in hospital phanmany. This model helps enhance patient trust and satisfaction with pharmaceutical services and provides practical evidence and reference for optimizing and promoting modern hospital pharmacy management models.