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Comparison of Remimazolam Tosilate and Propofol for General Anesthesia in Pediatric Patients Undergoing Laparoscopic High Ligation of the Hernial Sac
Received date: 2025-09-30
Revised date: 2025-10-22
Accepted date: 2025-12-24
Online published: 2026-01-26
Supported by
Objective： To compare the efficacy and safety of remimazolam tosilate versus propofol in general anesthesia for pediatric patients undergoing laparoscopic high ligation of the hernial sac.Methods： Sixty children aged 2 to 6 years， classified as ASA Ⅰ or Ⅱ， who underwent laparoscopic high ligation of the hernial sac under laryngeal mask general anesthesia in our hospital from March 2024 to November 2024 were included and randomly divided into the remimazolam group （group R， n=30） and the propofol group （group P， n=30）. In group R， anesthetic induction utilized remimazolam tosilate （hereinafter referred to as remimazolam）， sufentanil， and cisatracurium， with maintenance via remimazolam and remifentanil infusion. Group P received propofol， sufentanil， and cisatracurium for induction， followed by propofol and remifentanil maintenance. After the openation， all patients were transferred to the post-anesthesia care unit （PACU） for recovery management. The primary outcome was the sedation success rate. Secondary outcomes included hemodynamic parameters （MAP， HR， SpO2） during induction， operative duration， anesthesia duration， time of laryngeal mask removal， time of consciousness recovery， PACU discharge time， and the incidence of adverse events.Results： The sedation success rate in group R was not statistically different from that in group P （P > 0.05）. The MAP at T1 and T2 time points during induction in group R was higher than that of group P （P < 0.05）. No statistically significant differences were observed in recovery time， laryngeal mask removal time， PACU stay duration， or the incidence of postoperative adverse events （P>0.05）.Conclusions： Remimazolam demonstrates non-inferior efficacy to propofol for general anesthesia in children aged 2-6 years undergoing laparoscopic high ligation of the hernial sac， with superior hemodynamic stability during induction. These findings support remimazolam as a safe and viable alternative for general anesthesia for laparoscopic surgery in this pediatric population.
Key words： Remimazolam； ; Propofol； ; Pediatric anesthesia； ; Inguinal hernia； ; Hemodynamic stability
FAN Gaofei, ZHENG Kesong, WANG Hongtao, HAN Mingming, LI Juan, KANG Fang
.
Comparison of Remimazolam Tosilate and Propofol
for General Anesthesia in Pediatric Patients Undergoing Laparoscopic High
Ligation of the Hernial Sac
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