Objective： To analyze the influence of Shugan Tiaopi Tongfu decoction combined with targeted therapy and chemotherapy on immune function， fatigue level and quality of life in patients with liver stagnation and spleen deficiency type of advanced colorectal cancer.Methods： 90 patients with advanced colorectal cancer of liver stagnation and spleen deficiency type in department of oncology of our hospital were selected from February 2021 to August 2024， and were divided into the control group （n=45） and the experimental group （n=45） according to the random number table method. The control group was given bevacizumab combined with chemotherapy or fruquintinib combined with chemotherapy， while the experimental group was given Shugan Tiaopi Tongfu decoction on the basis of the treatment of control group， and both groups were treated for 3 months. The clinical efficacy， TCM syndrome efficacy， immune function， fatigue level and quality of life of the patients were compared between the two groups after the treatment， and the occurrence of adverse reactions was recorded.Results： After treatment， there was no statistical difference in the disease objective response rate between the experimental group （40.00%） and the control group （31.11%） （P>0.05）. After treatment， the TCM syndrome efficacy in the experimental group （93.33%） was higher than that in the control group （75.56%） （P<0.05）. The levels of peripheral blood CD3⁺， CD4⁺ and CD4⁺/CD8⁺ of patients in the experimental group after treatment rose compared with those before treatment， and were higher than those in the control group （P<0.05）. After treatment， the scores of dimensions of somatosensory fatigue， behavioral fatigue， emotional fatigue and cognitive emotional fatigue and total score of Piper Fatigue Scale-Revised （PFS-R） of patients in the two groups declined compared with those before treatment， and the above scores in the experimental group were lower than those in the control group （P<0.05）. After treatment， the score of functional area of Quality of Life Questionnaire-Colorectal Cancer （QLQ-CR38） of patients in the two groups increased， and the score was higher in experimental group （P<0.05）， and the score of QLQ-CR38 symptom area in both groups reduced compared to before treatment （P<0.05）， and the score of patients in the experimental group was lower than that in the control group （P<0.05）. During treatment， the incidence of adverse reactions in the experimental group was 57.78% （26/45）， which was lower than 77.78% （35/45） in the control group （P<0.05）.Conclusion： For patients with advanced colorectal cancer of liver stagnation and spleen deficiency type， Shugan Tiaopi Tongfu decoction is helpful to enhance the TCM syndrome efficacy， improve the immune function， reduce the fatigue level， and then improve the quality of life.