CHINESE JOURNAL OF MEDICINAL GUIDE >
Association Between Remnant Cholesterol and Cardiovascular and Cerebrovascular Diseases in Middle-aged and Elderly Population
Received date: 2025-08-07
Revised date: 2025-10-12
Accepted date: 2026-03-18
Online published: 2026-03-19
Objective： To explore the association between remnant cholesterol （RC） and cardiovascular and cerebrovascular diseases in middle-aged and elderly people.Methods： Based on the CHARLS database， 9302 participants aged ≥ 45 years were prospectively followed up for 9 years （2011-2020）. According to the RC tertile， the population was divided into three groups： Q1， Q2 and Q3. KM curve was used to analyze the correlation between RC level and cardiovascular and cerebrovascular diseases in different groups. The relationship between RC and the occurrence ofcardiovascular and cerebrovascular diseases was analyzed by univariate and multivariate Cox regression.Results： There were significant differences in age， gender， BMI， smoking， place of residence， hypertension and diabetes between different RC levels （P < 0.05）. The KM curve showed that the cumulative incidence of cardiovascular disease and stroke increased with the increase of RC level， and the difference between groups was significant （P < 0.001）. Cox regression analysis showed that RC was a significant risk factor for cardiovascular and cerebrovascular diseases. After uncorrected （Model 1）， partially corrected （Model 2） and fully corrected （Model 3）， RC as a continuous variable was significantly associated with the risk of cardiovascular disease and stroke （all HR > 1， P < 0.05）， and the risk continued with the increase of correction factors. Cox regression analysis using RC tertile classification revealed that Q2 and Q3 were risk factors for cardiovascular disease in Models 1-3 （both HR > 1， P < 0.05）； In Models 1 and 2， Q2 and Q3 were risk factors for stroke （both HR > 1， P < 0.05）， while in Model 3， only Q3 was a risk factor for stroke ［HR （95% CI） 1.30 （1.08-1.55）， P = 0.005］.Conclusion： In the middle-aged and elderly population， RC is an independent risk factor for cardiovascular and cerebrovascular diseases. The higher the level， the greater the risk of disease. The management of people with high RC levels should be strengthened to prevent cardiovascular and cerebrovascular diseases.
Key words： Remnant cholesterol； ; Cardiovascular disease； ; Stroke； ; Risk factors
Zunupiya Wufuli
.
Association Between Remnant Cholesterol and
Cardiovascular and Cerebrovascular Diseases in Middle-aged and Elderly
Population
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