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The Prognostic Value of Linc00173， RGS17， and HIF-2α in Postoperative Recurrence and Metastasis of Clear Cell Renal Cell Carcinoma
Received date: 2025-04-07
Revised date: 2025-09-02
Accepted date: 2026-03-18
Online published: 2026-04-21
Objective： To investigate the value of serum levels of Linc00173， G-protein signaling protein-17 （RGS17） and hypoxia-inducing factor （HIF） 2α in the recurrence and metastasis of renal clear cell carcinoma （ccRCC） after surgery.Methods： Data of 102 patients with ccRCC who received combined treatment in multiple hospitals in Shanghai， Nantong and Nanjing from October 2017 to April 2021 were retrospectively analyzed as the ccRCC group. 100 patients with renal benign tumor diagnosed at the same period were included as control group. Relevant data and serum levels of Linc00173， RGS17 and HIF-2α were collected and compared between the two groups. Multivariate Logistic and ROC curve were used to analyze the relationship between the above detection indicators and recurrence and metastasis in ccRCC patients.Results： The Serum levels of Linc00173， RGS17 and HIF-2α in ccRCC group were higher than those in control group （P<0.05）. The levels of Linc00173， RGS17 and HIF-2α in relapse-metastasis group were higher than those in non-relapse-metastasis group （P<0.05）. Tumor size ≥7 cm， clinical stage III~IV， high expression of Linc00173， RGS17 and HIF-2α were independent risk factors for postoperative recurrence and metastasis in ccRCC patients （P<0.05）. Body mass index ≥25 kg·m-2 had no significant correlation with recurrence and metastasis in patients with ccRCC （P>0.05）. ROC analysis showed that The area under the curve （AUC） of Linc00173， RGS17， and HIF-2α for predicting the recurrence and metastasis of ccRCC was 0.870 （95%CI=0.776-0.964）， 0.889 （95%CI=0.795-0.984）， and 0.814 （95%CI=0.710-0.917）， respectively. All of them had certain predictive value for the recurrence and metastasis of ccRCC （P<0.05）， and the combined AUC for predicting postoperative recurrence and metastasis of the three was the largest， which was 0.981 （95%CI=0.960-1.000）， with a sensitivity of 96.00% and a specificity of 89.61%.Conclusion： The high expression of serum Linc00173， RGS17 and HIF-2α are independent risk factors for postoperative recurrence and metastasis of ccRCC， and their combined detection provides a reliable basis for clinical evaluation of postoperative recurrence and metastasis.
ZHANG Yu, CHEN Xingjie, HUANG Yeqing, CAI Siqi, ZHANG Shuai, ZHANG Xiaopeng
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The Prognostic Value of Linc00173， RGS17， and HIF-2α in Postoperative
Recurrence and Metastasis of Clear Cell Renal Cell Carcinoma
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