Research Progress on the Mechanism and Treatment of Colorectal Polyps Complicated with Inflammatory Bowel Disease

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  • 1.Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Jiangsu Nanjing 210022, China
    2.Jiangsu Provincial Clinical Medicine Innovation Center for Traditional Chinese Medicine Anorectal Diseases Jiangsu Nanjing 210022, China;3.Nanjing Clinical Medicine Research Center for Traditional Chinese Medicine Anorectal Diseases Jiangsu Nanjing 210022, China;4.Nantong Hospital Affiliated to Nanjing University of Chinese Medicine Jiangsu Nantong 226000, China

Received date: 2025-09-29

  Revised date: 2025-12-16

  Accepted date: 2026-03-18

  Online published: 2026-04-21

Abstract

Patients with inflammatory bowel disease IBD have a significantly increased risk of developing colorectal polyps which represent a critical precancerous lesion for IBD‑associated colorectal cancer. Elucidating the underlying mechanisms and optimizing preventive and therapeutic strategies therefore hold substantial clinical value. Chronic intestinal inflammation drives aberrant activation of key signaling pathways including Wnt/β‑catenin and STAT3 which serves as the core mechanism of polyp formation and directly leads to dysregulated proliferation and differentiation of intestinal epithelial cells. In addition epigenetic abnormalities caused by imbalanced DNA methylation patterns and mutations in genes such as TP53 together with disturbances in the gut microbiota accompanied by metabolic alterations in bile acids and short‑chain fatty acids interact with inflammatory responses to form a vicious cycle that further promotes the development and progression of colorectal polyps. Current clinical management centers on standardized endoscopic surveillance and minimally invasive interventions supplemented by pharmacologic agents such as 5‑aminosalicylic acid along with lifestyle modifications and microecological modulation. Potential diagnostic biomarkers including SATB2 and ATF6 have also been identified. However existing research still faces challenges such as fragmented mechanistic insights insufficient multicenter validation of biomarkers and a lack of specific preventive and therapeutic agents. Future efforts should focus on deciphering key molecular targets using multi‑omics technologies and establishing individualized precision prevention and treatment strategies.


Cite this article

DUAN Meng, WANG Pei, DONG Yujing, ZHOU Peng, CHEN Weijie, FAN Zhimin .

Research Progress on the Mechanism and Treatment of Colorectal Polyps Complicated with Inflammatory Bowel Disease

[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2026 , 28(3) : 276 -283 . DOI: magtech.2025.09.29-00001

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