Research and Progress on the Role of IL-33 in Chronic Atrophic Gastritis

  • 腾 马
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  • 1.The First Clinical Medical College Heilongjiang University of Chinese Medicine Heilongjiang Haerbin 150040, China
    2.The First Affiliated Hospital Heilongjiang University of Chinese Medicine Heilongjiang Haerbin 150040, China

Received date: 2025-09-19

  Revised date: 2025-11-23

  Accepted date: 2026-05-26

  Online published: 2026-05-26

Abstract

 Chronic atrophic gastritis CAG is a disease characterized mainly by atrophy of the intrinsic glands of the gastric mucosa and intestinal metaplasia. Its features include thinning of the gastric mucosa thickening of the mucosal basal layer and possibly accompanied by metaplasia of the pyloric glands and intestinal glands or atypical hyperplasia. It is often associated with factors such as Helicobacter pylori H. pylori infection bile reflux long-term use of non-steroidal anti-inflammatory drugs alcohol intake and autoimmunity. In recent years relevant studies have shown that interleukin-33 IL-33), as a pleiotropic cytokine can play a key role in the progression of CAG by regulating inflammation autophagy and the immune microenvironment. This study aims to provide a new perspective for the clinical treatment of CAG by systematically summarizing the molecular mechanism pathological mechanism contribution and clinical transformation potential of IL-33 in CAG.


Cite this article

腾 马 .

Research and Progress on the Role of IL-33 in Chronic Atrophic Gastritis

[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2026 , 28(4) : 400 -400-408 . DOI: 10.1009-0959.2026.050003

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