CHINESE JOURNAL OF MEDICINAL GUIDE >
Research Progress in Traditional Chinese Medicine Interventions for Withdrawal Symptoms Protracted Benzodiazepine
3.Shanghai Mental Health Center, Shanghai 200030, China
Received date: 2025-11-10
Revised date: 2025-12-31
Accepted date: 2026-02-06
Online published: 2026-08-17
Benzodiazepines (BZDs) are commonly used in clinical practice for their sedative, anxiolytic, and hypnotic effects. However, inappropriate use patterns, including overuse and misuse, often lead to abuse or dependence. Modern medicine primarily manages acute BZD withdrawal symptoms through substitution tapering therapies and adjunctive pharmacological interventions, aiming to control seizures and other serious complications. Beyond the acute phase, patients frequently experience protracted withdrawal symptoms, characterized by persistent physical discomfort such as anxiety and insomnia lasting from weeks to years. These symptoms not only severely impact patients' overall recovery and quality of life but also become a significant reason for relapse. Currently, there is a lack of specific and sustained effective pharmacological treatments for protracted BZD withdrawal symptoms, representing a major clinical challenge. Traditional Chinese Medicine (TCM), with its unique diagnostic and therapeutic approaches rooted in the "holistic concept" and "syndrome differentiation and treatment", has demonstrated promising potential in alleviating protracted drug withdrawal symptoms. Based on recent research developments, this article systematically reviews the current treatment status, TCM pathological mechanisms, and advances in TCM interventions for protracted BZD withdrawal symptoms. It aims to integrate the strengths of both Western and Chinese medicine in withdrawal symptom management, explore the construction of a synergistic integrated treatment model, and provide a theoretical foundation and practical pathways for optimizing clinical practice and promoting patient rehabilitation.
QIU Xiaoling, LIU Eryue, WEI Haiyan, HUANG Rui, XU Shifen, DU Jiang
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Research Progress in Traditional Chinese Medicine
Interventions for Withdrawal Symptoms Protracted Benzodiazepine
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