文章摘要
张媚.拉莫三嗪治疗癫痫伴抑郁的临床疗效及对认知功能的影响[J].中国医药导刊,2017,19(10):1010-1013.
拉莫三嗪治疗癫痫伴抑郁的临床疗效及对认知功能的影响
The Clinical Efficacy of Lamotrigine in the Treatment of Epilepsy with Depression and the Influence on Cognitive Function
投稿时间:2017-06-06  修订日期:2017-09-26
DOI:
中文关键词: 癫痫  抑郁  拉莫三嗪  认知功能
英文关键词: Epilepsy  Depression  Lamotrigine  Cognitive function
基金项目:国家自然科学基金项目(项目编号:81301010;项目名称:小剂量TPC对脑出血SVZ细胞迁移、增生、分化的影响)
作者单位E-mail
张媚 武汉市第五医院 zhzngqiumin@sina.com 
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中文摘要:
      目的:观察拉莫三嗪治疗癫痫伴抑郁的临床疗效及对患者认知功能的影响。方法:将我院收治的68例癫痫伴抑郁患者随机分为观察组和对照组两组,每组病例数均为34例。对照组患者行托吡酯治疗,观察组患者行拉莫三嗪治疗。治疗12周后,分别对两组患者的临床治疗效果进行评价;两组患者治疗前后采用汉密尔顿抑郁量表(HAMD)分别评价抑郁症状积分;采用简明智能精神状况检查量表(MMSE)分别评价患者的认知功能。结果:观察组患者临床治疗总有效率为91.17%,对照组为88.24%,两组比较,差异无统计学意义(P>0.05);在平均HAMD评分上,组间比较,治疗前两组比较,差异无统计学意义(P>0.05);治疗8周后及12周后,观察组HAMD评分均较对照组低(P<0.05)。组内比较,两组患者治疗8周后及12周后较治疗前降低(P<0.05)。治疗12周后,两组患者平均MMSE评分较治疗前均升高(P<0.05),但观察组患者平均MMSE评分均高于对照组(P<0.05)。结论:拉莫三嗪治疗癫痫伴抑郁的临床疗效显著,对患者抑郁症状及认知功能的改善效果良好。
英文摘要:
      Objective:To observe the clinical effect of lamotrigine in the treatment of epilepsy with depression and the influence on the cognitive function of the patients.Methods:68 patients with epilepsy and depression in our hospital were randomly divided into observation group (n=34) and control group (n=34). The control group patients were treated with topiramate.The observation group was treated with lamotrigine.After 12 weeks of treatment,therapeutic effect of 2 groups were evaluated.Depressive symptom score was evaluated in 2 groups of patients before and after treatment using Hamilton Depression Scale (HAMD) respectively,and patients′ cognitive function were evaluated with concise mental state examination scale (MMSE).Results:The clinical total effective rate was 91.17% in observation group, and 88.24% in the control group.There was no statistically significant difference(P>0.05).On the average HAMD score, there was no significant difference between the two groups before the treatment (P>0.05). After 8 weeks and 12 weeks, the HAMD scores of the observation group were lower than that of the control group (P<0.05).In group comparison, the 2 groups decreased after treatment 8 weeks and 12 weeks after treatment (P<0.05). After 12 weeks of treatment, the average MMSE score of the patients in both groups was higher than that before treatment (P<0.05), and the average MMSE score of the observation group was higher than that of the control group (P<0.05). Conclusion:The clinical curative effect of lamotrigine in the treatment of epilepsy with depression is significant, and can effectively improve the symptoms of depression and cognitive dysfunction.
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