文章摘要
李放.甲氨蝶呤联合米非司酮治疗异位妊娠的疗效[J].中国医药导刊,2017,19(10):1023-1025.
甲氨蝶呤联合米非司酮治疗异位妊娠的疗效
The Curative Effects of Methotrexate Combined with Mifepristone in the Treatment of Ectopic Pregnancy
投稿时间:2017-06-07  修订日期:2017-08-13
DOI:
中文关键词: 甲氨蝶呤  米非司酮  异位妊娠  安全性  有效性
英文关键词: Methotrexate  Mifepristone  Ectopic pregnancy  Safety  Efficacy
基金项目:江苏大学医学临床科技发展基金(项目编号:JLY20140025;项目名称:经阴道超声引导宫外孕包块药物注射术研究)
作者单位E-mail
李放 镇江市中西医结合医院妇产科 江苏 镇江 212000 happy66gg@126.com 
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中文摘要:
      目的:探讨甲氨蝶呤(MTX)联合米非司酮治疗异位妊娠的疗效。方法:选取我院2010年1月至2016年12月收治的异位妊娠患者36例,采用甲氨蝶呤联合米非司酮进行治疗。结果:本组36例患者经治疗后治愈18例、好转12例、效6例,总有效率为83.3%。与治疗前相比,治疗后患者的血β-HCG 水平、血孕酮水平及包块大小均明显降低。治疗后,患者出现胃肠道反应6例(16.7%)、白细胞减少0例(0.0%)、肝功能异常5例(13.9%)、肾功能异常7例(19.4%),总发生率为50.0%。结论:局部注射甲氨蝶呤结合米非司酮治疗异位妊娠的临床疗效显著,可显著降低β-HCG水平、血孕酮水平及包块大小,预后较为良好,安全性较高。
英文摘要:
      Objective:To explore the curative effects of methotrexate(MTX) combined with mifepristone in the treatment of ectopic pregnancy.Methods:36 cases of ectopic pregnancy treated in our hospital from January 2010 to December 2016 were selected and treated with methotrexate combined with mifepristone.Results:After treatment,18 cases were cured,12 cases were improved and 6 cases were ineffective that the total effective rate was 83.3%.After treatment,the levels of serum β-HCG and serum progesterone and the size of the mass were significantly reduced than those before treatment.After treatment,there were 6 cases with gastrointestinal reaction (16.7%),0 case with white blood cell reduction,5 cases with abnormal liver function (13.9%)and 7 cases with abnormal renal function(19.4%)that the total rate was 50%.Conclusion:Injection of methotrexate combined with mifepristone of the clinical curative effect in the treatment of ectopic pregnancy is significant,which can significantly reduce the level of β-HCG and blood progesterone and the size of the package,at the same time.
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