文章摘要
高翔,张帆,兰昱,王娜,刘盈,沈秉正.ADV联合多烯磷脂酰胆碱治疗CHB及对细胞因子影响[J].中国医药导刊,2017,19(10):1018-1022.
ADV联合多烯磷脂酰胆碱治疗CHB及对细胞因子影响
Effects of Adefovir Dipivoxil Combined with Polyene Phosphatidylcholine on Serum Cytokines in Patients with Chronic Hepatitis B
投稿时间:2017-08-23  修订日期:2017-08-23
DOI:
中文关键词: 慢性乙型肝炎  阿德福韦酯  多烯磷脂酰胆碱  血清细胞因子水平
英文关键词: Chronic hepatitis B  Adefovir dipivoxil  Polyene phosphatidyl choline  Serum cytokine level
基金项目:湖北省自然科学基金青年项目(项目编号:2015CFB350;项目名称:过氧化氢介导的信号通路在调控植物发育和抗病中的作用和机制研究);病毒学国家重点实验室开放研究基金资助项目(项目编号:2016KF002;项目名称:新型蝎毒素多肽Ctri2123抗HCV研究)
作者单位E-mail
高翔 武汉大学人民医院 中心实验室 358501984@qq.com 
张帆 武汉大学人民医院药学部  
兰昱 武汉大学人民医院药学部  
王娜 武汉大学人民医院药学部  
刘盈 武汉大学人民医院药学部  
沈秉正 武汉大学人民医院药学部 drug_shen@126.com 
摘要点击次数: 353
全文下载次数: 95
中文摘要:
      目的:研究慢性乙型肝炎(CHB)患者使用阿德福韦酯(ADV)联合多烯磷脂酰胆碱药物治疗后4种血清细胞因子白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-21(IL-21)和肿瘤坏死因子(TNF-α)水平的变化。方法:筛选我院就诊且符合纳入标准的CHB患者48例,其中20例单用ADV进行抗乙肝病毒治疗, 28例使用ADV联合多烯磷脂酰胆碱进行治疗。分别在单用或联用药物进行抗病毒药物治疗前后检测HBV-DNA载量、HBeAg转阴率及血清中细胞因子IL-6、IL-10、IL-21和TNF-α的含量。结果:与单用抗乙肝病毒药ADV相比,与多烯磷脂酰胆碱联合使用能更好地降低HBV-DNA载量、提高乙型肝炎E抗原(HBeAg)转阴率,降低IL-6(P=1.08×10-3)和TNF-α(P=4.1×10-2)因子水平,同时升高IL-10(P=1.88×10-5)和IL-21(P=3.5×10-2)水平,能更好改善患者肝脏功能,差异有统计学意义。 结论:将抗乙肝病毒药ADV与保肝护肝药多烯磷脂酰胆碱合用能取得更好的治疗效果,提高患者生活质量。
英文摘要:
      Objective:To explore the the serum cytokine level of IL-6,IL-10,IL-21 and TNF-α in chronic hepatitis B(CHB) patients before and after the treatment of adefovir dipivoxil(ADV) combined with polyene phosphatidylcholine.Methods:48 patients with CHB who came to our hospital were selected according to the inclusion criteria. Of them,20 patients were treated with ADV,and the other 28 patients were treated with ADV combined with polyene phosphatidylcholine.HBV-DNA loads, HBeAg seroconversion rates and the level of serum cytokine IL-6,IL-10,IL-21 and TNF-α were detected before and after the treatment of medications.Results:Compared to the treatment of ADV alone,combing ADV with polyene phosphatidylcholine decreased HBV-DNA loads, increased the overcast rates of HBeAg,and displayed stronger ability to reduce the level of IL-6 (P=1.08×10-3) and TNF-α (P=4.1×10-2),enhanced the level of IL-10 (P=1.88×10-5) and IL-21 (P=3.5×10-2),and improved liver function. The differences were statistically significant.Conclusion: Combination therapy with ADV plus polyene phosphatidylcholine greatly improved liver function and quality of life.
查看全文   查看/发表评论  下载PDF阅读器