文章摘要
王帆.系统性红斑狼疮生存分析的单中心回顾性研究[J].中国医药导刊,2017,19(10):973-976.
系统性红斑狼疮生存分析的单中心回顾性研究
A Single Center Retrospective Study of Survival in Patients with Systemic Lupus Erythematosus
投稿时间:2017-09-26  修订日期:2017-09-26
DOI:
中文关键词: 系统性红斑狼疮  首发症状  死亡原因  生存分析  预后因素
英文关键词: Systemic lupus erythematosus  First onset symptom  Cause of death  Survival analysis  Prognostic factor
基金项目:国家自然科学基金(项目编号:81302559;项目名称:双歧杆菌通过肠道DC上调Foxp3+T细胞在类风湿关节炎中的作用及机制研究);十三五南京市卫生青年人才培养工程(项目编号:QRX17122)
作者单位E-mail
王帆 南京大学医学院附属南京鼓楼医院 270043834@qq.com 
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中文摘要:
      目的:总结系统性红斑狼疮(SLE)首发症状死亡原因和影响预后的因素。方法:记录收集2001年1月1日至2009年12月31日我院风湿免疫科住院的200名患者的临床表现、实验室检查结果和用药等情况,并随访至2017年6月30日的生存情况,进行描述性统计、单因素方差分析、生存分析以及Cox单因素和多因素回归分析。结果:颊部红斑、关节炎为最常见的首发症状。1、3、5、10年生存率分别为99.0%,96.4%,95.4%,89.3%。其中31例死亡,主要死亡原因为感染、心肺及大血管受累、肾功能衰竭。入院时病程>2年,心脏呼吸累及的患者死亡风险较高,而使用抗疟药的患者死亡率降低。入院时病程>2年和抗dsDNA抗体阳性是SLE预后不佳的独立危险因素。结论:病程较长、心脏呼吸系统累及及抗dsDNA抗体阳性的SLE患者预后较差,抗疟药对SLE患者有保护作用。
英文摘要:
      Objective: To summarize the first onset symptoms,causes of death and prognostic factors in patients with systemic lupus erythematosus(SLE). Methods: Clinical manifestations,laboratory examination and medication of 200 inpatients in rheumatology department of our hospital from January 1st,2001 to December 31st, 2009 were collected and followed up to June 30th, 2017. Statistical methods included descriptive analysis, one-way ANOVA,survival analysis,Cox’s proportional hazards regression model. Results:The most common onset symptoms were malar rash and arthritis. The survival rates of 1,3,5 and 10 years were 99.0%,96.4%, 95.4%,89.3%,respectively. 31 cases died. The main causes of death were infection, cardiopulmonary involvement and renal failure. The risk of death was higher in patients with cardiopulmonary involvement and those whose disease course more than 2 years,while mortality was lower in patients treated with antimalarial drugs. Duration of disease more than 2 years and anti-dsDNA antibody positive were independent risk factors for poor prognosis of SLE. Conclusion: The prognosis of SLE patients with longer disease course,cardiopulmonary involvement,and anti dsDNA antibody positive is poor. Antimalarial drugs have protective effects on SLE patients.
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