Abstract: Objective:To investigate the related factors,characteristics,prevention measures of orthopia operation on operation ECG changes.Method:Observation the ECG operation changes of 200 orthopia operation patients,summarized prevention measures.Results:The children and general anesthesia patients were more prone to oculocardiac reflex,the oculocardiac reflex of medical rectus and inferior obliquus at a higher rate,over 90%,were significantly higher than other oculorotatory muscle(P<0.05).The bigest ECG changes of operation were sinus bradycardia,far higher than other ECG change number(P<0.05).The incidence of the oculocardiac reflex(37.8%)of preoperative application atropine patients was lower than no application atropine patients(76.2%),the incidence had statistical difference(χ 2 = 5.44,P<0.05).Conclusion:age,anesthesia mode influent the oculocardiac reflex of orthopia operation,the ECG change had certain rules when oculocardiac reflex occurs,application atropine preoperative may reduce the incidence of oculocardiac reflex.