Abstract: Objective:The 3-Dimension Powerful Doppler Ultrasonic was adopted to analyze quantitatively the relationship between the perfusion indices of blood flow inside the kidney and the measured values of kidney function so as to know the degree of the kidney damage of chronic kidney disease(CKD) patients caused by primary renal glomerular diseases.Methods: 60 cases of primary renal glomerular diseases were involved in the study group according to the diagnosis and staging criteria of Kidney Disease Survival Quality Instruction made by NKF(K/DOQI) compared with 30 cases as the normal control group.The Colorful Doppler Ultrasonic was adopted to observe the morphology and structure of kidney and show the filling of blood flow in various branches of arteries.The pulse Doppler was adopted to show the pulse Doppler spectrum of the segmental and interlobal arteries of kidney.The resistance index(RI) was also detected.The kidney blood perfusion imaging was observed by 3-dimension powerful Doppler ultrasonic and the vessel indices(VI) was calculated by the blood flow analysis technology.The kidney blood flow perfusion parameters were compared with the measured values of kidney function and the biopsy pathology results.Results: Significant difference of blood flow perfusion imaging,resistance indices(RI) and vessel indices(VI) of all levels of arteries existed between the primary kidney glomerular disease group and normal control group while it became more and more apparent as the kidney function was injured more and more severely.Conclusion:The 3-Dimension Powerful Doppler Ultrasonic can observe the kidney blood perfusion at various stages of CKD so that it can provide objective basis for the evaluation of early kidney function injury of primary renal glomerular diseases.