Abstract: Objective:Study and discussion on the relationship between high risk exposure and Stroke risk in order to achieve primary prevention.Methods:2005 January-2008 January,Jun Gong Hospital 2000 outpaiten-ts are selected voluntarily,who have at least one of Stroke risk factors,which are hypertension、diabetes、heart disease、tobacco and alcohol history and family history of stroke,whose CVHI should be less than 75 by doppler probe and the pressure sensing probe of cerebral vascular hemodynamic monitor to study carotid artery of cerebral vascular hemodynamic detection and risk factors.Each patient are followed up for 4 years since the date of treatment,the last of them is followed up to 2012 January.Endpoint is Stroke,during 4 years 105 patients are off.Results:Following the score of CVHI decreasing Stroke risk is increasing significan-tly,which is P<0.001,and Stroke events occur earlier with reducing of the score of CVHI;Their relationship are very close between hypertension、diabetes、heart disease、tobacco and alcohol history and stroke,which is P<0.05,especially hypertension,which is P<0.001.Conclusion:The score of CVHI decreased is an independent risk factor of stroke;Their relationship are very close between common risk factors and stroke,especially hypertensIon.