Abstract: 【ABSTRACT】Objective: To investigate the clinical application of damage control surgery (DCS) in the treatment of multiple injuries in the emergency surgery. Methods: 60 cases of multiple injury patients were randomly divided into experimental group and control group, 30 cases in each. The experimental group using DCS, the control group using the traditional treatment methods, compared two groups of patients with operation time, blood loss, temperature recovery time, diffuse intravascular coagulation(DIC) the incidence, treatment success rate and mortality differences. Analysis the therapeutic effect of two groups of patients. Results: Patients in the experimental group bleeding volume, body temperature recovery time, lactic acid recovery time, ATT, Pt recovery time were significantly lower than those of the control group(P＜0.05). There was no significant difference (P＞0.05) between the two groups of patients at the time of surgery. The incidence of DIC in the experimental group, the incidence of complications and mortality were significantly lower than those in the control group (P＜0.05). Conclusion: For multiple trauma patients, using DCS, can improve the clinical treatment effect and treatment success rate, reduce complications, reduce the mortality rate.