Abstract: [Abstract] Objective:To analyze and investigate the efficacy and safety of carvedilol United spironolactone in elderly patients with chronic heart failure.Methods:100 ases of patients with elderly patients with chronic heart failure in our hospital from Deceber 2012to Deceber 2014 were selected,divided into the observation group and the control group,each were 50 examples,patients in the control group were given routine treatment,patients in the observation group were given carvedilol United spironolactone therapy based on the routine treatment,3 months for a course of treatment, clinical curative effect and adverse reactions occur of the two groups were compared after treatment.Results:In the observation group,36 cases were markedly, 11 cases were effectively,3 cases were invalid, the total effective rate was 94%,In the control group,17 cases were markedly, 15 cases were effectively,18 cases were invalid, the total effective rate was 64%,the differences between the two groups were all significantly（P＜0.05）;In the observation group, the incidence of adverse reaction was 6%, reduce drug dosage, symptoms gradually disappear,there was no adverse reactions occurred in control group,the difference between the two groups was not statistically.Conclusion:carvedilol United spironolactone applied in the clinical treatment of the elderly patients with chronic heart failure,Curative effect is exact, and can improve the cure rate, reduce the mortality rate, and with less adverse reactions,we suggest that in clinical application.