Abstract: Abstract: objective: to analysis the chronic obstructive pulmonary disease (copd) with type Ⅱ BiPAP ventilator application in treatment of respiratory failure.Methods: between January 2011 and December 2014 in our hospital for treatment of copd with type Ⅱ 84 patients with respiratory failure were then divided into control group and observation group, 42 cases, control group given low flow oxygen joint respiratory stimulants, observation group line BiPAP ventilator ventilation, comparing two groups of clinical effect.Results: 6 h, 24 h, 72 h after treatment, the observation group of patients with heart rate (HR), respiratory (RR), arterial blood (PaCO2) co2 partial pressure, blood oxygen partial pressure improved (PaO2) and PH value were superior to control group, the treatment success rate is higher than the control group, the mortality rate is lower than the control group, significant difference (P < 0.05), all have statistical significance.Conclusion: copd combined Ⅱ type used in treatment of respiratory failure BiPAP ventilator can effectively improve the patient's vital signs and blood gas analysis index, reduce mortality, significant clinical value.