Abstract: 【ABSTRACT】Objective: To compare the immune function effects of different surgical treatment for the gallbladder polyps in the elderly patients.Methods:From August 2011 to February 2015,accorded to the randomized controlled double-blind principles,112 elderly patients with gallbladder polyps in our hospital,were equally into the treatment group and the control group.Patients in the treatment group were received laparoscopic combined choledochoscope gallbladder polyp removal surgery,those in the control group were received conventional laparoscopic cholecystectomy.Results:The blood loss,postoperative defecation time and postoperative hospital stay in the treatment group were significantly less than the control group (P＜0.05). The postoperative 1d and 7d of peripheral blood CD3+ and CD3+ CD8+ lymphocytes absolute values in the two groups were significantly lower than the absolute value of preoperative (P＜0.05),but the postoperative 1d and 7d of peripheral blood CD3+ and CD3+ CD8+ lymphocytes absolute values in the treatment group were significantly higher the control group(P＜0.05).The postoperative abdominal distension,jaundice,nausea and vomiting,lung infections and other complications in the treatment group were significantly lower than the control group (P＜0.05).Postoperative 3 months investigation,the physical functioning,role function,cognitive function,emotional function and social function in the treatment group were significantly higher (P＜0.05). Conclusion:Compared with cholecystectomy,laparoscopic combined choledochoscope gallbladder polyp removal surgery treatment of elderly patients with gallbladder polyps has better minimally invasive and security,it can promote the recovery of immune function in patients,thus it is contributes to the overall quality of life improvement.