Abstract: 【ABSTRACT】Objective: To evaluate the value of quantitative analysis in the benign and malignant breast nodules by ultrasonic elastosonography strain ratio(SR).Methods:68 cases of breast patients (72 breast nodules) in our hospital were included in the study.All of the breast nodules were examined by ultrasonic elastography from which the SR were derived,compared with the pathological results,and the ROC curve was used to identify the best threshold for differential diagnosis of breast nodules.Results: Through the histological pathology confirmation of 72 breast nodules,44 nodules were benign and 28 nodules were malignant. Analyzed the results by ultrasonic elastography,The SR of malignant nodules were (0.35±0.14),benign nodules were (1.06±0.68),P＜0.01,It showed that the optimal operating point was 0.40,with high sensitivity(90.2%),specificity(89.3%)and accuracy (90.6%),The area under the ROC curve was 0.912.Conclusion:SR has a high accuracy to judge the benign and malignant breast nodules and it has good application values.