Abstract: 【ABSTRACT】Objective: To research microwave ablation to prolong survival of patients with lung cancer, to reduce the adverse reaction of action.Methods: Randomly selected during July 2013 to December 2014, our hospital 64 cases of advanced lung cancer patients, as the research object, its averaged were divided into control group and observation group.control group patients with chemotherapy, observation group implemented microwave ablation treatment.In view of the two groups of patients with clinical treatment, survival period, adverse reactions indicators were observed and compared.Results: In this study, the observation group of patients with clinical response rate was 84.38%, control group patients was 62.50%, P＜0.05,there was statistical significance. Observation group of patients survival rate was 96.88% at 6 months, the control group the survival rate was 78.13%, P＜0.05, there was statistical significance.Observation group of patients with 1 year survival rate was 87.50%, the control group the survival rate of 62.50%, P＜0.05, there was statistical significance.Observation group of patients the incidence of adverse reactions was 9.38%, the control group the incidence of adverse reactions was 37.50%, P＜0.05, there was statistical significance.Conclusion: In this study, the implementation of microwave ablation in patients with lung cancer, can significantly improve the patient's clinical treatment effect and prolong survival in patients with stage, reduce the incidence of adverse reactions in patients with treatment, the overall treatment effect is remarkable, high safety and effectiveness.