Abstract: 【ABSTRACT】Objective: To analyze the changes of blood lipid levels in the office population, and to provide evidence for the management of blood lipids.Method:2366 people 25~54 year old office worker according to age every 10 years period is divided into six groups (A, B, C, D, E, F Group), from 2010~2012 the changes of blood lipid level trend, comparative 2012 between men and women,blood lipid level, blood lipid and age adjusted mean(YZ) difference analysis, analysis of lipids with the age trend.Results: (1)In 6 groups of TG, TC, LDL-C, non-HDL-C in 2010~2012 years showed a rising trend, HDL-C was decreased year by year, each time trend effect was linear results (P＜0.05).(2)In 2012, A, B group, TG, TC, LDL-C, non-HDL-C were higher than in group D and E, HDL-C were significantly lower than those in group D and E; TG in group C than that in group F, TC, HDL-C below group F (P＜0.05).(3) In 2012, B,C, F group TC was higher than that of YZ; A, B, C, E, F group LDL-C than YZ; A, B, C, D, E group HDL-C than YZ; A, B, C, F group non-HDL-C than YZ (P＜0.05).(4)The men and women of TC, TG, LDL-C, non-HDL-C value in each year was positively correlated with age (P＜0.05).Conclusion: The blood lipids in the office population increased year by year from 2010~2012, and the risk factors of cardiovascular events were increased in men and women in peri menopausal period.