胺碘酮治疗急诊危重症合并快速心律失常患者的疗效及安全性研究

胺碘酮治疗急诊危重症合并快速心律失常患者的疗效及安全性研究

陈新光

北京市普仁医院急诊科

收稿日期:2017-09-20 修回日期:2017-09-20 出版日期:2017-10-25
基金资助:
国家自然科学基金（项目编号：81400308；项目名称：AMPK介导ghrelin拮抗体外循环心肌缺血再灌注损伤的作用和机制研究）

Efficacy and Safety of Amiodarone in the Treatment of Patients with Acute Critical Disease and Rapid Arrhythmia

chen xin guang

Beijing Puren Hospital

Received:2017-09-20 Revised:2017-09-20 Online:2017-10-25

摘要/Abstract

摘要： 目的：分析胺碘酮治疗急诊危重症合并快速心律失常患者的疗效及安全性。方法：将2014年6月至2016年6月入住我院的120例急诊危重症合并心律失常患者采用随机数字表法将其分为对照组和观察组两组，每组各60例，其中对照组患者给予去乙酰毛花苷注射液治疗，观察组患者给予胺碘酮注射液治疗，比较两组患者的治疗总有效率、不良反应发生率以及各项心功能指标情况。结果：观察组患者治疗总有效率（93.33%）明显高于对照组（68.33%），差异有统计学意义（P＜0.05）；观察组患者不良反应发生率（16.67%）明显低于对照组（43.33%），差异有统计学意义（P＜0.05）；观察组患者各项心功能指标情况明显优于对照组，差异有统计学意义（P＜0.05）。结论：静脉注射胺碘酮能有效控制急诊危重症合并心律失常，安全性高。

Abstract: Objective： To investigate the efficacy and safety of amiodarone in the treatment of patients with acute critical disease and rapid arrhythmia. Methods： 120 cases of acute critical disease with arrhythmia in our hospital from June 2014 to June 2016 were collected and randomly divided into observation group and control group， 60 cases in each group.Patients in the control group were treated with deslanoside injection， while those in the observation group received amiodarone injection treatment.The overall effective rate，incidence of adverse reactions and cardiac function indexes of the patients were compared between the two groups.Results：The total effective rate of the observation group (93.33%) was significantly higher than that (68.33%) of the control group (P<0.05).The incidence of adverse reactions in the observation group (16.67%) was significantly lower than the control group (43.33%， P<0.05). The cardiac function of the patients in the observation group was significantly better than that of the control group (P<0.05). Conclusion： Intravenous injection of amiodarone can be an effective and safe treatment to patients of acute and critical disease with rapid arrhythmia.

陈新光. 胺碘酮治疗急诊危重症合并快速心律失常患者的疗效及安全性研究[J]. .

chen xin guang. Efficacy and Safety of Amiodarone in the Treatment of Patients with Acute Critical Disease and Rapid Arrhythmia[J]. .

参考文献

[1] 邹德玲,刘兴利,方悦,等.胺碘酮与艾司洛尔治疗老年患者急性心肌梗死合并室性心律失常的短期疗效与安全性比较[J].药物用药不良现象杂志,2014,16(2)：86-90.
[2] 柏山,王玉荣,戴家瑗.胺碘酮与西地兰控制心脏围术期快心室率房颤疗效观察[J].实用临床医药杂志,2013,17(23)：117-118.
[3] Triggiani V,Iacoviello M,Monzani F,et a1.Incidence and prevalence of hypothyroidism in patients effected by chronic heart failure:role of amiodarune[J].Endocr Metab Immune Disord Drug Targets,2012,12(1):86-94.
[4] 谢芸芝,陶蓉,蒋东坡.急诊应用胺碘酮治疗快速性心律失常的临床分析[J].重庆医学,2013,42(15)：1722-1726.
[5] Marinelli A, Capucci A smooth Amiodarone (Nexterone) injection for the treatmentand prophylaxis of frequently recurring ventricular fibrillation[J].Expert Opin Pharmacother,2012,13(4):573-584.
[6] 张培勇.不同剂量美托洛尔联合胺碘酮治疗快速型心律失常的疗效[J].心血管康复医学杂志,2014,13(3)：297-300.
[7] 魏琳萍,王鸣燕.胺碘酮与美托洛尔治疗快速性心律失常患者的疗效[J].安徽医学,2014,10(4)：511-512.
[8] Laqueille X,Riehs, Kerbage H,et al.Chang Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone[J].Encephale,2012,38(1):58-63.
[9] 于晓钧.胺碘酮与西地兰治疗急诊危重症合并快速心律失常的疗效比较[J].现代中西医结合杂志,2013,22(34)：3819,3821.
[10] 王国敏,莫淑琴.急诊应用胺碘酮治疗冠心病快速心律失常的临床疗效[J].中国老年学杂志,2014(9)：2539-2541.
[11] Bardy GH,Lee KL,Mark DB,et al.Amiodarone or implantable cardiover-defibrillatorfor congestive heart failure[J].The New England Journal of Medicin,2013,12(12):1021-1022.
[12] 张煜,张清艳,金兆辰,等.胺碘酮联合硫酸镁治疗顽固性室性心律失常的疗效与安全性[J].中国临床药理学杂志,2014,12(9)：325-326.
[13] 李莉娟,郭大峰,杨胜.应用胺碘酮治疗急诊患者中各种不同类型的快速性心律失常的安全性和有效性分析[J].中国实用医药,2015,10(17)：152,154.
[14] Rathore SS,Berger AK,Weinfurt KP,et a1.Acute myocar-dial infar-ction by atrial fibrillation in the elderly：prevalence and outcomes[J].Circulation,2013,55(10):665-669.
[15] 敖勇.胺碘酮治疗急诊快速型心律失常临床疗效与安全性分析[J].医学综述,2014,20(16)：3024-3026.[1] 邹德玲,刘兴利,方悦,等.胺碘酮与艾司洛尔治疗老年患者急性心肌梗死合并室性心律失常的短期疗效与安全性比较[J].药物用药不良现象杂志,2014,16(2)：86-90.
[2] 柏山,王玉荣,戴家瑗.胺碘酮与西地兰控制心脏围术期快心室率房颤疗效观察[J].实用临床医药杂志,2013,17(23)：117-118.
[3] Triggiani V,Iacoviello M,Monzani F,et a1.Incidence and prevalence of hypothyroidism in patients effected by chronic heart failure:role of amiodarune[J].Endocr Metab Immune Disord Drug Targets,2012,12(1):86-94.
[4] 谢芸芝,陶蓉,蒋东坡.急诊应用胺碘酮治疗快速性心律失常的临床分析[J].重庆医学,2013,42(15)：1722-1726.
[5] Marinelli A, Capucci A smooth Amiodarone (Nexterone) injection for the treatmentand prophylaxis of frequently recurring ventricular fibrillation[J].Expert Opin Pharmacother,2012,13(4):573-584.
[6] 张培勇.不同剂量美托洛尔联合胺碘酮治疗快速型心律失常的疗效[J].心血管康复医学杂志,2014,13(3)：297-300.
[7] 魏琳萍,王鸣燕.胺碘酮与美托洛尔治疗快速性心律失常患者的疗效[J].安徽医学,2014,10(4)：511-512.
[8] Laqueille X,Riehs, Kerbage H,et al.Chang Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone[J].Encephale,2012,38(1):58-63.
[9] 于晓钧.胺碘酮与西地兰治疗急诊危重症合并快速心律失常的疗效比较[J].现代中西医结合杂志,2013,22(34)：3819,3821.
[10] 王国敏,莫淑琴.急诊应用胺碘酮治疗冠心病快速心律失常的临床疗效[J].中国老年学杂志,2014(9)：2539-2541.

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