Abstract: Objective： To investigate whether detection of N-terminal pro-brain natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF) could be an early death risk assessment for patients with AMI.Methods：248 cases of AMI were collected from January 2015 to July 2016 through emergency department and were divided into survival group and death group according to the survival within the first 28 days.220 cases in the survival group (157 male， 63 female) and 28 cases in the death group (21 male，7 female).Clinical data like age，gender，chief complaint of chest pain， prehospital time，electrocardiogram(ECG) before treatment，whether received percutaneous coronary intervention(PCI) and appeared early adverse cardiac events or not，survival within 28 days， cardiac troponin I(cTnI)， NT-proBNP，LVEF，etc were recorded.Logistic regression analysis，ROC curve and Cox regression model were utilized to analyze the predictive value of LVEF and NT-pro BNP for early death of AMI.Results：Compared with the death group，age，levels of D-dimer and NT-proBNP were lower in the survival group[(68.0±11.6)y vs (73.5±7.6)y，P=0.002； (213.5±359.4)ng·mL-1 vs (685.7±624.9)ng·mL-1， P=0.000； (1796.4±3863.8) ng·mL-1 vs (6325.0±9951.8) ng·mL-1，P=0.002]，while no significant difference was observed in prehospital time，cTnI and LVEF.The incidence of typical chest pain complaint and ST-segment elevation of ECG in the survival group was significantly higher than that in the death group. Multivariate logistic regression analysis showed that LVEF values was negative correlated with LVEF(B=-0.001，P＝0.000). Although only age was positive correlated with 28 d death (B=0.141，P＝0.023).The combination of LVEF and NT-proBNP was positive correlated with 28 d death (B=6.49，P＝0.000).The ROC curves showed that the area under the curve of 28 d mortality from the combination of two factors was 0.918.Conclusion： Assessments of LVEF and NT-proBNP are correlated with the early death risk of patients with AMI.