Abstract: Objective：To explore clinical features and correlated risk factors of prognosis of sepsis patients， then provide basis for improving prognosis of sepsis. Methods：Retrospectively collecting 115 cases data of sepsis patients， these cases were divided into death group(n=40) and survival group(n=75) according to the prognosis. With Case-Control study method， the correlated risk factors of prognosis death of sepsis were analyzed by single and multiple factors analysis methods. Results：The death rate of sepsis prognosis was 34.8%(40/115). Multiple factors analysis result showed that the factors of age(OR=7.071)， complication of acute kidney injury(OR=4.175)， the numbers of organ failure(OR=2.440)， urea nitrogen(OR=3.080)， C reactive protein(OR=1.859) and APACHEⅡ score(OR=5.256) were the risk factors of sepsis prognosis. Conclusion：The death rate of sepsis prognosis lies in a high rate. The high risk factors of sepsis prognosis include high age， complication of acute kidney injury， multiple organ failure， urea nitrogen and C reactive protein increased， high APACHEⅡ score. Intervention measures should be adopted to aim directly at these high risk factors.