Abstract: Objective：To evaluate the safety and efficacy of SLIPA laryngeal mask in airway management for gynecological laparoscopic surgeries under general anesthesia. Methods： Eighty patients who underwent elective gynecologic laparoscopic surgery with ASA status Ⅰ~Ⅱ were enrolled and randomly divided into SLIPA laryngeal mask group (S group) and endotracheal intubation group (T group). Time for intubation and the success rate at the first attempt were recorded. Measurements of mean arterial pressure(MAP)， heart rate (HR) and oxygen saturation (SpO2) at baseline(T0)， 1 min (T1) after intubation， 3 min(T2) after intubation， immediately before extubation (T3)，and 1 min after extubation (T4) were collected. Airway peak pressure (Ppeak)， tidal volume (Vt)， End-tidal CO2 partial pressure(PETCO2) were compared between two groups before and after establishing pneumoperitoneum， as well as intubation-related complications. Results： MAP and HR of the T group at points of T1， T3 and T4 were significantly higher than those at T0 as well as those of the S group (P<0.05). MAP of the S group at T2 was significantly lower than T0 (P<0.05).Satisfying controlled ventilation were achieved in both groups and no significant differences in Ppeak， VT and PETCO2 were observed between the two groups (P>0.05). Ppeak and PETCO2 after were significantly higher than those before establishing pneumoperitoneum (P<0.05). Intubation time in the S group was significantly shorter than the T group (P<0.05). There was no significant difference in first-attempt success rate between two groups. There was significant difference between the two groups as in complications during extubation and postoperative 24 h(P<0.05). Conclusion： SLIPA laryngeal mask is safe and feasible for airway management in gynecological laparoscopic surgeries， with satisfying ventilation but less intubation responses.