Abstract: Objective：To investigate the clinical efficacy and complications of the transabdominal， transvaginal and laparoscopic myomectomy. Methods： 150 myomectomy patients were divided into 3 groups， which were laparotormy group， transvaginal group and laparoscopic group， 50 cases in each group. They were performed transabdominal， transvaginal and laparoscopic myomectomy respectively.The intraoperative and postoperative conditions，postoperative complications， postoperative curative effect and the level of C-reactive protein (CRP) in the 3 groups were observed respectively. Results：The operation time in the laparoscopic group was significantly longer than those of the transvaginal group and the laparotomy group，while the anal exhaust time and hospitalization time in the laparoscopic group were significantly shorter than those of the transvaginal group and the laparotomy group (P<0.05).The intraoperative bleeding volume in the transvaginal group was less than those of the laparotomy group and the laparoscopic group (P<0.05). The incidence of postoperative complications in the laparotomy group was 18%， higher than 8% in the transvaginal group， 6% in the laparoscopic group，the difference was statistically significant (χ2=7.77，P<0.05). Serum CRP concentrations after surgery were significantly higher than those before surgery in all groups (P<0.05). The postoperative serum CRP levels in the laparotomy group were significantly higher than those of the other two groups， which had statistical significance（F=89.7，P<0.05）. Conclusion：Transvaginal myomectomy and laparoscopic myomectomy are less invasive and have less complications， and deserve further promotion in clinical practice.