Abstract: Objective：To analyze the correlation between serum immunoglobulin and prognosis in children with cough variant asthma. Methods：From January 2014 to January 2016， 68 patients with cough variant asthma treated in pediatric department of our hospital were selected as the case group. According to the ACT score and the cough symptom score， the children in the case group were divided into mild group (42 cases) and severe group (26 cases). 30 healthy children with similar age and accepted physical examination at the same time were enrolled in control group. The levels of immune globulin-E（IgE）， interleukin 6（IL-6）， interleukin 8（IL-8） and tumor necrosis factor-α（TNF-α） were measured by ELISA， and the risk factors that related to exacerbation of allergic cough were analyzed. Results：The levels of IgE， IL-6， IL-8 and TNF-α in serum in the case group were significantly higher than those in the control group， and the levels of IgE， IL-6， IL-8 and TNF-α in severe group were higher than the mild group， and there was statistical significance (P<0.05). Pearson correlation analysis showed that the severity of cough was positively correlated with the levels of IgE， IL-6， IL-8 and TNF-α (P<0.05). IgE， IL-6， IL-8， TNF-α， cough symptom score and ACT score were used as independent variables that inducing allergic cough， multivariate logistic regression analysis showed that IgE， IL-6， IL-8， TNF-α， cough symptom score and ACT score were all the risk factors of cough variant asthma in children (P<0.05). The factors of OR value>1 in multivariate logistic regression model were analyzed by the ROC curve， the area of ROC curve (AUC) showed IgE>ACT score> cough symptom score>IL-6>TNF-α>IL-8.Conclusion：IgE， IL-6， IL-8 and TNF-α are the risk factors of allergic cough， and with the increase of IgE， cough variant asthma may worsen in children.