Abstract: Objective：To analyze the correlation between chronic prostatitis and male immune infertility.Methods： Retrospectively analysis 176 cases of male infertility patients with clinical data， according to whether complicated with chronic prostatitis patients were divided into two groups； control group of 97 patients without chronic prostatitis； observation group of 79 patients with chronic prostatitis. The semen quality of the two groups of the patients was commpared by semen liquefaction time， sperm motility， sperm concentration and normal morphology. Use spearman correlation analysis to evaluate the relationship between chronic prostatitis and the semen quality of male immune inferfility patients. Results： The semen liquefaction time in the observation group was longer than that in the control group， the sperm motility rate and the normal morphology rate were lower than those in the control group， and the sperm concentration was higher than that in the control group. The differences were statisticlly significant(P<0.05).Spearman correlation analysis showed that chronic prostatitis was positively correlated with sperm liquefaction time of male immune infertility patients， and was negatively correlated with sperm motility， sperm concentration and normal morphology rate(P<0.05).Conclusion： The occurrence and development of male immune infertility may be related to chronic prostatitis， because chronic prostatitis can reduce the quality of semen， which provides the basis for clinical treatment of male immune infertility.