Abstract: Objective：To investigate the clinical efficacy of polyene phosphatidylcholine combined with vitamin E in the treatment of nonalcoholic fatty liver disease. Methods：The clinical datas of 134 patients with nonalcoholic fatty liver disease were reviewed and analyzed. The data were collected from May 2016 to May 2017.The enrolled patients were assigned to a group study， in which polyene phosphatidylcholine group (67 patients) were given polyene phosphatidylcholine， and the combined treatment group (67 patients) was treated with polyene phosphatidylcholine combined with vitamin E. The blood lipid level and liver function of the two groups were detected before and after treatment. The curative effect was determined and the adverse reactions were recorded.Results： After treatment， the serum lipid levels and liver function indexes of the two groups were significantly decreased， but the decrease in the combined treatment group was more obvious. After treatment， there were significant differences between the two groups (P<0.05). The total effective rate of the combined treatment group was significantly higher than that of polyene phosphatidylcholine group (89.55% vs 77.61%， P<0.05).There were some adverse reactions in the two groups， but the overall rate was mild， which did not affect the treatment schedule， and there was no significant difference between the two groups (all P>0.05). Conclusion： Polyene phosphatidylcholine combined with vitamin E in the treatment of nonalcoholic fatty liver disease curative is effective， compared with polyene phosphatidylcholine treatment can better improve the patient′s liver function and blood lipid， improve the treatment efficiency， and has good safety.