脑梗死患者血清胱抑素C,hs-CRP及D-二聚体与颈动脉斑块稳定性的研究

脑梗死患者血清胱抑素C,hs-CRP及D-二聚体与颈动脉斑块稳定性的研究

曲明卫,吴慧君,张福波,范桂梅,杨潮萍,张丽华▲

沧州市中心医院神经内科,沧州市中心医院神经内科,沧州市中心医院神经内科,沧州市中心医院神经内科,沧州市中心医院神经内科,沧州市中心医院神经内科

收稿日期:2017-06-07 修回日期:2017-08-02 出版日期:2017-08-25
基金资助:
沧州市科技支撑计划项目(项目编号：162302176；项目名称：急性脑梗死患者血清胱抑素C，hs-CRP及D-二聚体与颈动脉斑块稳定性的相关研究)

Study on the Relationship between Serum Cystatin C，hs-CRP， D-dimer and the Stability of Carotid Plaque in Patients with Cerebral Infarction

QU Mingwei,WU Huijun,ZHANG Fubo,FAN Guimei,YANG Chaoping and ZHANG Lihua

Department of Neurology,Cangzhou Central Hospital,Department of Neurology,Cangzhou Central Hospital,Department of Neurology,Cangzhou Central Hospital,Department of Neurology,Cangzhou Central Hospital,Department of Neurology,Cangzhou Central Hospital,Department of Neurology,Cangzhou Central Hospital

Received:2017-06-07 Revised:2017-08-02 Online:2017-08-25

摘要/Abstract

摘要： 目的：探讨脑梗死患者中血清胱抑素C（cystain C，Cys C）、超敏C-反应蛋白（hypersensitive C-reactive protein，hs-CRP）及D-二聚体（D-Dimer）水平与颈动脉斑块稳定性的关系。方法：选取我院急性脑梗死患者100名，并选取同期我院行健康体检的健康对照者80名，测定所有受试者的血清胱抑素C，hs-CRP及D-二聚体的水平，并应用彩色多普勒超声检测受试者的颈动脉内中膜厚度（IMT）及动脉粥样硬化斑块性质，加以分析评价。结果：脑梗死组血清胱抑素C、hs-CRP及D-二聚体水平显著高于对照组（P<0.01，P<0.01及P<0.05），病例组中不稳定斑块组中血清胱抑素C、hs-CRP及D-二聚体高于稳定斑块组（P<0.01，P<0.01及P<0.05）。结论：血清胱抑素C、hs-CRP及D-二聚体水平升高不仅与脑梗死的发生发展有关，还与颈动脉斑块的性质及稳定性相关，临床中应早期监测，早期预防和治疗。

Abstract: Objective：To investigate the relationship between serum cystatin C，hs-CRP and D-dimer levels and the stability of carotid plaques in patients with cerebral infarction. Methods：A total of 100 patients with acute cerebral infarction were enrolled in this study.80 healthy controls were collected from our hospital.The levels of serum cystatin C，hs-CRP and D-dimer were tested； IMT and atherosclerotic plaque properties of the subjects were analyzed by color doppler ultrasonography.Results：The levels of serum cystatin C， hs-CRP and D-dimer in the cerebral infarction group were significantly higher than those in the control group (P<0.01， P<0.01 and P<0.05). In the unstable plaque group， serum levels of cystain C， hs-CRP and D-dimer were higher than those in stable plaque group (P<0.01， P<0.01 and P<0.05). Conclusion：Serum levels of cystatin C，hs-CRP and D-dimer were elevated in patients with cerebral infarction， not only relevant with the occurrence and development of cerebral infarction， but also with the nature and stability of carotid plaques， clinical early monitoring， early prevention and treatment.

曲明卫,吴慧君,张福波,范桂梅,杨潮萍,张丽华▲. 脑梗死患者血清胱抑素C,hs-CRP及D-二聚体与颈动脉斑块稳定性的研究[J]. .

QU Mingwei,WU Huijun,ZHANG Fubo,FAN Guimei,YANG Chaoping and ZHANG Lihua. Study on the Relationship between Serum Cystatin C，hs-CRP， D-dimer and the Stability of Carotid Plaque in Patients with Cerebral Infarction[J]. .

参考文献

[1]Shen B, Liu Q,Gu Y,et al.Efficacy and Safety Evalution on Arterial Thrombolysis in Treating Acute Cerebral Infarction[Ｊ].Cell Biochem Biophys,2015,73(2):297-304.
[2]Leng XY,Chen XY,Chook P,et,al.Correlation of large artery intracranial occlusive disease with carotid intima-media thickness and presence of carotid plaque [Ｊ].Stroke.2013;44(1):68-72.
[3]Romano FA,Campo-Bustillo JG,Campo I,et al.High-dose atorvastatin enhances impaired cerebral vasomotor reactivity[Ｊ].Journal of stroke and cerebrovascular disease,2012,24(6):537.
[4]Mogelvang R,Pedersen SH,Flyvbjerg A,et al.Comparison of osteoprotegein to traditional atherosclerotic risk factors and high-sensitivity C-reactive protein for diagnosis of atherosclerosis[Ｊ].Am J Cardiol,2012,109(4):515-520.
[5]Doganer Yc,Aydogan U,Aydogdu A,et al.Relatiaonship of cystatin C with coronary artery disease and its severity [Ｊ].Coron Artery Dis,2013,24(2)119-126.
[6]Lee M,Saver JL,Huang WH,et al.Impact of elevated cystatin level on population amete-analysis[Ｊ].Cardiovasc Qual Outcomes,2010,3：675-683.
[7]Flynn RWM,MacDonald TM,Murray GD,et al.Persistence,adherence and outcome with antiplatelet regiments following cerebral infarction in the Tayside Stroke Cohort[Ｊ].Cerebrovascular dieeases,2012,30(2):519.
[8]Roudbary SA,Saadat F,Forghanparast K,et al.Serum C-reactive protein level as a biomarker for differentiation of ischemic from hemorrhagic stroke [Ｊ].Acta Med Iran,2011,49(3):149-152.
[9]Youn CS,Choi SP,Kim SH,et al.Serum hightly selective protein concentration is associated with the volume of ischemic tissue in acute ischemic stroke[Ｊ].Am J Emerg Med,2012,30:124-128.
[10]Lind M,Boman K,Johansson L,et al.D-dimer predicts major bleeding,cardiovascular events and all-cause mortality during warfarin treatment[Ｊ].Clin Biochem,2014,47(7/8):570-573.

快速检索引用检索图表检索高级检索