Abstract: Objective： To explore the serum levels of TC， TG， LDL-C and HDL-C in the pregnancy women with preeclampsia （PE）， and their clinician value. Methods：From April 2012 to April 2016， 72 cases of PE women were selected， which were divided into mild preeclampsia （MPE） （n=38）， severe preeclampsia （SPE） （n=34）. In addition， 65 cases of normal pregnant woman were selected as the control group. The levels of serum triglycerides （TG）， total cholesterol （TC）， low-density lipoprotein （LDL-C） and high-density lipoprotein cholesterol （HDL-C） were detected by biochemical quantitative method. We also selected 147 cases of severe preeclampsia women from June 2015 to May 2016， which were randomly divided into labetalol treated group （n=75） and nifedipine administrated group （n=72）. Then we detected the levels of TC， TG， LDL-C and HDL-C in severe preeclampsia women before and after treatment. Results：The serum levels of TC， TG， LDL-C in PE pregnant woman were obviously higher than the normal group whereas the serum levels of HDL-C in PE pregnant woman were obviously lower than the normal group. In addition， we also found that the serum TC， TG， LDL-C levels in mild preeclampsia woman were markedly increased but HDL-C level was decreased when compared with normal group. Furthermore， the serum TC， TG， LDL-C levels in severe preeclampsia woman were markedly increased but HDL-C level was decreased when compared with mild preeclampsia woman. Our results also showed that labetalol treatment and nifedipine administration significantly attenuated the increases in serum levels of TC， TG， LDL-C and the decrease in serum HDL-C level in severe preeclampsia woman. Conclusion：The increased content of serum TC， TG， LDL-C as well as the reduced level of serum HDL-C are closely related to the development of preeclampsia， which still reflect the severity of preeclampsia in a way and labetalol as well as nifedipine can effectively control the levels of TC， TG， LDL-C and HDL-C in severe preeclampsia patients.