Abstract: Objective：To improve the quality standard of changyanning granules through quality control research by adjusting the type and amount of excipients of changyanning granules. Methods：Thin layer chromatography (TLC) was used to identify the Hedyotis chrysotricha and Euphorbia humifusa in changyanning granules. The high performance liquid chromatography (HPLC)method was used to determine the content of gallic acid in Euphorbia humifusa， Folium Liquidambaris and Hedyotis chrysotricha in changyanning granules. Results：The characteristic spots of seopoletin and the reference crude drug of Euphorbia humifusa were detected by TLC method.The HPLC method showed that the gallic acid contained in Euphorbia humifusa， Folium Liquidambaris， Hedyotis chrysotricha had a good linear relationship.The precision， repeatability and recovery rate were all good， and the solution was stable within 24 h. The method can be used for the determination of gallic acid content of changyanning granules. The gallic acid content of three batches of samples was determined using a validated content determination method. Conclusion：This established method is simple， feasible and specific， and can effectively control the quality of changyanning granules and improve the quality standards.