Abstract: Objective：To explore the effects of combined spinal-epidural labor analgesia at different times during cervical dilatation on parturients and newborns. Methods：363 cases of pregnant women who delivered at LDR ward of international medical department in our hospital during November 2016 to October 2017 were selected as subjects.They were randomly divided into the experimental group Ⅰ(n=84)，group Ⅱ(n=92)，group Ⅲ (n=99)and the control group (group Ⅳ， n=88). The time of labor analgesia in the experimental group (3 groups) was： group Ⅰ pregnant women cervix<3 cm， group Ⅱ 3 cm ≤cervix<4 cm， group Ⅲ cervix ≥4 cm. The control group was full-term primipara without labor analgesia and had no pregnancy complications.Observe the differences at following aspects which include the time of three stages of labor， postpartum hemorrhage，anxiety score and depression score，postpartum urinary retention，and newborns′ Apgar score. Results： The shortest time of the first and second stages of labor was group Ⅱ， the least bleeding amounts at 2 h was group Ⅰ， the lowest anxiety and depression score was group Ⅰ， the highest score of 5 min′s newborns′Apgar score was group Ⅱ， the least of urinary retention was group Ⅲ. Conclusion：The different time of labor analgesia have both advantages and disadvantages. Optimal analgesia time can be selected by appropriate care intervention.