Abstract: Objective：To investigate the relationship between cardiac calcification and coronary heart disease（CHD）. Methods：From January to December 2016， a total of 775 hospitalized suspected patients with CHD participated in this study. Transthoracic echocardiography was used to assess the severity of calcification in mitral annulus， aortic root and aortic valve. Coronary angiography was performed to determine the extent of coronary lesion during the same period. Results： Compared with no-calcium deposits group，patients in calcium deposits group were older（P<0.05），and the proportion of patients with hypertension increased（P<0.05）. Compared with no-calcium deposits group， the ratio of patients with hypercholesterolemia and diabetes mellitus rised in subgroups of multiple calcium deposits（P<0.05）. In subgroup of three calcium deposits， amount of males was less， and the values of left ventricular end-diastolic diameter（LVEDD） increased while left ventricular ejection fraction（LVEF） reduced（P<0.05）. Positive rate of coronary angiography increased as cardiac calcification enhanced gradually（P<0.05）. Single vessel lesion was frequent in patients of no calcium deposits group（P<0.05） while left main and multiple branches coronary disease were prevalent in subgroup of multiple calcium deposits（P<0.05）. By logistic analyses，multiple calcium deposits might be a new independent predictor for the positive prevalence of coronary heart disease（P=0.004）. Conclusion：Cardiac calcification assessment by transthoracic echocardiography is an effective means for significantly predicting the severity of CHD.