Abstract: Objective：To explore the clinical nursing points of hepatic venous occlusive disease. Methods： A total of 100 patients with hepatic venous occlusive disease who were treated in our department from January 2016 to July 2017 were randomly assigned to the control group and the observation group， each group 50 cases. The control group was given routine care, the observation group was given targeted care, and the care effects of the two groups were compared. Results： The effective rate of the observation group was higher than that of the control group, and the difference was significant(P<0.05). Conclusion： In the care of patients with hepatic venous occlusive disease, symptom observation, psychological care and health education can improve the symptoms of patients with hepatic venous occlusive disease, promote early recovery of patients and improve their quality of life.